正交试验优选黄芪桂枝五物汤提取工艺研究  

Optimization for extraction technology of Huangqi Guizhi Wuwu decoction by orthogonal experimental design

作　　者：孙学惠[1] 陈宇峰[1] 吴琼[1] 董立峰[1] 史国兵[1] 

机构地区：[1]中国人民解放军沈阳军区总医院,110016

出　　处：《山西医药杂志（上半月）》2013年第5期486-488,共3页Shanxi Medical Journal

基　　金：军队中医药科研专项课题(10ZYZ201)

摘　　要：目的正交试验优选黄芪桂枝五物汤提取工艺。方法采用正交实验法,以黄芪甲苷、芍药苷和出膏率为综合评分指标,以溶剂量、提取时间、提取次数为考察因素,各设置3个水平,对黄芪桂枝五物汤提取工艺进行优化。结果黄芪桂枝五物汤的最佳提取工艺条件为10倍水量,提取2次,每次1h为最优工艺。结论优选的提取工艺对各指标性成分的提取率均较高,可以为制剂生产提供依据。Objective To optimize the extraction technology of Huangqi Guizhi Wuwu decoction. Methods The contents of Astragaloside IV, paeoniflorin and the extract yield was used as the analysis indexes. The ex- traction technology was optimized through orthogonal experimental design by selecting solvent volume, extraction time and number of times as factors. Results The optimized extraction technology was as follows： extracting 2 times with 10 fold water, 1 hour each time. Conclusion The extraction technology showed higher efficiency for each indicated component and could provid basis for preparation manufacture.

关 键 词：黄芪 芍药 提取法 正交试验 

分 类 号：R284[医药卫生—中药学]