TCF7L2基因多态性与肾移植后糖尿病的相关性  

Association of TCF7L2 gene polymorphisms with posttransplantation diabetes mellitus in Chinese renal allograft recipients

作　　者：余爱荣[1] 范星[2] 刘慧明[1] 辛华雯[1] 

机构地区：[1]广州军区武汉总医院临床药理科武汉,430070 [2]肾内科广州军区武汉总医院肾内科武汉,430070

出　　处：《肾脏病与透析肾移植杂志》2013年第2期125-129,共5页Chinese Journal of Nephrology,Dialysis & Transplantation

基　　金：湖北省自然科学基金计划资助项目(2009CDB010)

摘　　要：目的:探讨转录因子7样2基因(TCF7L2)多态性与肾移植后糖尿病(PTDM)的相关性。方法:采用实时荧光定量PCR法检测97例PTDM患者(PTDM组)和301例未发生PTDM的肾移植受者(对照组)的TCF7L2基因rs290487的基因型,采用Logistic回归分析该基因多态性与PTDM的相关性。结果:PTDM组和对照组患者rs290487的基因型分布差异具有统计学意义。用性别、移植时年龄、体重和体质量指数等危险因素进行校正后,rs290487的CC基因型携带者在肾移植术后发生PTDM的风险是TT基因型携带者的2.300倍(OR=2.300,95%CI:1.196～4.425,P=0.013);CC+CT基因型携带者在肾移植术后发生PTDM的风险是TT基因型携带者的1.935倍(OR=1.935,95%CI:1.141～3.281,P=0.014)。结论:TCF7L2基因rs290487的多态性是中国肾移植受者发生PTDM的独立危险因素。Objective： To investigate the relationship of trascription factor 7 type 2 （TCF7L2） gene polymorphism with the risk of PTDM in Chinese renal allograft recipients. Methodology： A total of three hundred ninety eight unrelated renal allograft recipients without prior diabetes （97 patients with PTDM and 301 patients without PTDM） were genotyped for the presence of TCF7L2 gene rs290487 polymorphism by real-time fluorescence polymerase chain reaction （ real-time PCR）. Logistic regression method was used to identify risk factors for PTDM development and calculate the odds ratio （OR）. Results： The genotype distributions of rs290487 were significantly different between the PTDM patients and controls （P 〈 0. 05 ）. The effect of genotype remained significant （ CC vs TT, OR = 2. 300,95% CI： 1. 196 - 4. 425, P = 0. 013 ; CC ＋ CT vs IT, OR = 1. 935,95% CI ： 1. 141 - 3. 281, P = 0. 014） after adjustments for age, sex, body weight and body mass index （BMI）. Conclusion：The C-allele in rs290487 of TCF7L2 is the independent risk factors of PTDM in Chinese renal allozraft recinients.

关 键 词：肾移植后糖尿病 转录因子7样2基因 单核苷酸多态性 危险因素 

分 类 号：R699.2[医药卫生—泌尿科学]