线粒体钙离子转运的研究进展  

Research of Mitochondrial Calcium Transportation

作　　者：陆久维[1] 翟宇佳[1] 孙飞[1] 

机构地区：[1]中国科学院生物物理研究所生物大分子国家重点实验室,北京100101

出　　处：《生物物理学报》2013年第3期167-180,共14页Acta Biophysica Sinica

基　　金：国家"973"计划项目(2011CB910301);国家自然科学基金创新群体项目(31021062)~~

摘　　要：线粒体内的钙离子浓度对于线粒体的ATP合成、线粒体通透性转变孔道的开放及细胞质内钙信号的调节具有重要影响。线粒体的钙离子转运调节平衡是线粒体除合成ATP和诱导细胞凋亡以外的又一重要功能。线粒体中存在钙吸收和钙释放两种重要的钙转运机制。文章就线粒体外膜钙离子的转运、内膜钙离子的吸收和释放等线粒体钙离子转运方式的研究历史和最新研究进展进行了综述。The free calcium concentration in mitochondria has been found important to regulate the ATP synthesis rate of mitochondria, the open of the mitochondrial permeability transition pore and the calcium signaling of cytoplasm. The regulated balance between mitochondrial calcium influx and efflux is another important function of mitochondrion besides its essential roles in ATP production and cell apoptosis inducement. There are both calcium influx and efflux existing in mitochondria. The paper reviews the research history, as well as the recent research achievements of mitochondrial calcium transportation across outer membrane, mitochondrial calcium uptake via inner membrane and mitochondrial calcium release through inner membrane.

关 键 词：线粒体 钙离子吸收 钙离子释放 MCU NCLX 

分 类 号：Q71[生物学—分子生物学]