Ras/Raf/MEK/ERK通路在食管癌药物靶向治疗中的作用  

Roles of targeting Ras/Raf/MEK/ERK signaling pathways in the treatment of esophageal carcinoma

作　　者：昌毓穗[1] 刘季春[1] 傅华群[2] 喻本桐[1] 邹书兵[2] 吴起才[1] 万力[1] 

机构地区：[1]南昌大学第一附属医院胸心血管外科,江西南昌330006 [2]南昌大学第二附属医院普外科,江西南昌330006

出　　处：《药学学报》2013年第5期635-641,共7页Acta Pharmaceutica Sinica

摘　　要：Ras蛋白是调节细胞生长、增殖和分化的重要元件。当Ras变异时,可引起细胞的异常增殖,导致肿瘤的发生。胞外信号调控激酶(ERK)是Ras下游效应子,在恶性肿瘤细胞的生长和预后中扮演重要角色。近来研究证明,在Ras和ERK之间还存在其他相关的效应子,相互之间构成了一条完整的Ras/Raf/MEK/ERK信号通路,在食管肿瘤的发病过程中起着重要作用,部分针对该通路的抗肿瘤药物已在临床中应用。对于Ras/Raf/MEK/ERK信号通路中分子机制的进一步理解,可为制定更有效的食管肿瘤靶向治疗方法创造条件。本文就该信号通路在食管癌中的作用及药物靶点做一综述。Ras is best known for its ability to regulate cell growth, proliferation and differentiation. Mutations in Ras are associated with the abnormal cell proliferation which can result in incidence of all human cancers. Extracellular signal-regulated kinase （ERK） is a downstream effector of Ras and plays important roles in prognosis of tumors. Recently, evidence has gradually accumulated to demonstrate that there are other effectors between Ras and ERK, these proteins interact each other and constitute the thorough Ras/Raf/MEK/ ERK signaling pathway. The pathway has profound effects on incidence of esophageal carcinoma and clinical applications of some chemotherapeutic drugs targeting the pathway. Further understanding of the relevant molecular mechanisms of Ras/Raf/MEK/ERK signaling pathway can be helpful for the development of efficient targeting therapeutic approaches which contribute to the treatment of esophageal cancer. In this article, roles of Ras/Raf/MEK/ERK signaling pathway in esophageal carcinoma as well as pharmacological targeting point in the pathway are reviewed.

关 键 词：食管癌 信号通路 靶向治疗 

分 类 号：R963[医药卫生—微生物与生化药学]