拐芹根的化学成分研究  

Chemical constituents from the roots of Angelica polymorpha Maxim

作　　者：杨郁[1] 张杨[1] 任凤霞[1] 于能江 徐锐[1] 赵毅民[1] 

机构地区：[1]军事医学科学院毒物药物研究所,北京100850

出　　处：《药学学报》2013年第5期718-722,共5页Acta Pharmaceutica Sinica

基　　金：国家"十二五"重大专项重大新药创制资助项目(2012ZX09301003-001;2013ZX09102-018)

摘　　要：拐芹(Angelica polymorpha Maxim.)是伞形科当归属植物,其根、茎为民间用药,具有祛风散寒、消肿止痛的功效。为了研究拐芹根中的化学成分,经色谱分离从其80%乙醇提取物中得到了7个化合物,通过波谱分析鉴定了结构。化合物1是一个新的倍半萜,命名为没药烷吉内酯,经NOESY和CD分析确定了其绝对构型。其他化合物鉴定为5-羟甲基糠醛(2)、hycandinic acid ester 1(3)、阿魏酸(4)、异氧化前胡内酯(5)、去甲基丁香色原酮(6)、升麻素(7)。化合物2、3为首次从该属植物中分离得到,化合物4为首次从该植物中分离得到。Angelica polymorpha Maxim. is a plant of the Angelica genus （Umbelliferae）. The root and stem of this plant is a folk medicine known to have the actions of relieving rheumatism and cold and subsiding swelling and pains. To investigate the chemical constituents in the root of A. polymorpha Maxim., seven compounds were isolated from an 80% ethanol extract by column chromatography. Their structures were elucidated according to the spectroscopic analysis. Compound 1 is a new sesquiterpene, named as bisabolactone. Its absolute configuration was determined by 1D NOESY and CD analysis. The others were identified as 5-hydroxymethylfurfural （2）, hycandinic acid ester 1 （3）, ferulic acid （4）, isooxypeucedanin （5）, noreugenin （6） and cimifugin （7）. Compound 2 and 3 were isolated from this genus for the first time and compound 4 was isolated from this plant for the first time.

关 键 词：拐芹 倍半萜 香豆素 色原酮 酚酸 

分 类 号：R284.1[医药卫生—中药学]