高时空分辨率功能磁共振成像的光子流蒙特卡罗反馈方法(英文)  

Monte Carlo Code in Photon Migration Sensing Feedback with High Spatiotemporal Resolution Functional MRI

作　　者：邓梁 史仪凯[1] 张均田[2] 卢健康[1] 

机构地区：[1]School of Mechanical Engineering,Northwestern Polytechnical University [2]Department of Pharmacology,Institute of Materia Medica,Chinese Academy of Medical Sciences

出　　处：《航天医学与医学工程》2013年第2期79-82,共4页Space Medicine & Medical Engineering

基　　金：Supported by National Natural Science Foundation of China(51105316)

摘　　要：目的为了解决传统fMRI快速成像脉冲序列存在的空间分辨率相对低和时间分辨率低的固有问题,提出使用高时间分辨率脑皮层血氧动态光传感反馈技术,实现高空间分辨率MR成像。方法多周期事件刺激实验产生的脑皮层血氧动态响应,由MRI线圈时分式频域数据采集,成像序列磁脉冲发射由光传感反馈控制;设计了光子在3D MRI数字化脑皮层多光学性质介质中迁移的蒙特卡罗程序。结果脑皮层血氧响应状态及其重现状态能够精确光学监测,时分式k空间覆盖策略(TDC)成功采集高频数据。结论该理论和算法具有高时空分辨率的成像性能优点,为MRI时空成像提供了新的有效手段。Objective To solve the problem that fast imaging strategy of traditional fMRI is of relatively low spa- tial-resolution and inherently poor temporal-resolution, a new method is proposed to utilize high spatial-resolu- tion imaging pulse sequence stimulated with optoelectrical feedback, because optic technique has the advan- tage of high temporal-resolution. Methods With multi-periods events simulation, the imaging frequency data were sampled time divisionally and optic system tracked the hemodynamic response synchronizing MRI pulse e- mitting system. The Monte Carlo program was also introduced for photon migration through 3D MRI-based me- dium with spatially varying optical properties. Results The hemodynamic state and its reappearance in brain were precisely tracked by optic sensing and time-division coverage （TDC） of k-space was enforced. Conclu- sion The method offers high spatiotemporal resolution （HSR） imaging ability and provides a useful new tool for spatiotemporal MR imaging.

关 键 词：功能磁共振成像 时空成像 高分辨率 光子迁移 蒙特卡罗 

分 类 号：TP391[自动化与计算机技术—计算机应用技术]