药物超敏反应综合征23例临床分析  

Clinical Analysis of 23 Cases of Drug-induced Hypersensitivity Syndrome

作　　者：王琼[1] 冯义国[1] 许美凤[1] 董颖颖[1] 汪炜[1] 

机构地区：[1]西安交通大学医学院第二附属医院皮肤科,陕西西安710004

出　　处：《中国皮肤性病学杂志》2013年第5期475-477,共3页The Chinese Journal of Dermatovenereology

基　　金：国家自然科学基金(项目编号:30901298)

摘　　要：目的分析23例药物超敏反应综合征(DIHS)患者的临床表现和实验室检查的规律,以及对治疗的反应。方法回顾性分析了23例DIHS患者的临床表现、实验室检查、治疗效果、并发症及预后。结果本调查中100%的患者有用药史并出现发热,60.9%的患者皮疹表现为麻疹样疹,肝脏受累患者占87.0%,嗜酸粒细胞增多者占87.0%。严重的合并症包括6例患者转氨酶升高10倍以上,3例患者出现较严重肾损害,1例患者出现菌血症,1例患者出现酮症酸中毒,后2例患者死亡。治疗主要为系统使用糖皮质激素。结论 DIHS潜伏期长,皮损形态多样,脏器受累多以肝脏为主、肾脏次之。糖皮质激素治疗有效。Objective To analysis the pattern of clinical manifestations and laboratory test results of 23 DIHS patients, as well as their response to treatment. Methods The clinical manifestations, laboratory test results, re-sponse to treatment, complications and prognosis of all the 23 patients were analyzed retrospectively. Results In this research, 100% patients had a medication history and fever, 60.9% had urticaria, 87.0% had liver damage and 87.0% had hypereosinophilic syndrome. The patients with serious complications included six whose transaminase raised to more than 10 times normal, three with renal damage, one with bacteremia and one with diabetic ketoacidosis. The latter two patients died. The majority therapy was systematic use of glu-cocorticoid. Conclusion The incubation period of DIHS is long, the skin lesion is morphological diversity and visceral damage mainly involved in the liver, followed by the kidney. Glucocorticoid therapy is effective.

关 键 词：药物超敏反应综合征 药物性肝炎 嗜酸粒细胞增多 人6型疱疹病毒 

分 类 号：R758.25[医药卫生—皮肤病学与性病学]