京尼平作为交联剂在天然生物材料改性中的应用  

APPLICATION OF GENIPIN FOR MODIFICATION OF NATURAL BIOMATERIALS AS A CROSSLINKING AGENT

作　　者：王旻[1] 笪琳萃[1] 谢艳[2] 解慧琪[1] 

机构地区：[1]四川大学华西医院再生医学研究中心.干细胞与组织工程研究室,成都610041 [2]四川大学华西医院消化内科,成都610041

出　　处：《中国修复重建外科杂志》2013年第5期580-585,共6页Chinese Journal of Reparative and Reconstructive Surgery

基　　金：国家自然科学基金资助项目(31271058;81200333);国家高技术研究发展计划(863)资助项目(2012AA020503)~~

摘　　要：目的综述京尼平作为交联剂在天然生物材料改性中的应用及研究进展。方法查阅近年关于京尼平作为交联剂在天然生物材料改性中应用的相关文献,进行分析总结。结果天然交联剂京尼平交联效率高,细胞毒性显著低于传统人工合成的化学交联剂,交联后的生物制品稳定性强,抗酶解效果显著提高。结论京尼平有望替代人工合成的传统化学交联剂,为组织工程中天然生物材料的交联改性提供更好的选择。Objective To review the application of genipin for the modification of natural biomaterials as a crosslinking agent and progress in research. Methods Domestic and foreign literature on application of genipin for the modification of natural biomaterials as a crosslinking agent was thoroughly reviewed. Results Genipin is an effective natural crosslinking agent with a very low level of cytotoxicity compared with conventional synthetic crosslinking agents. Tissues fixed with genipin can maintain a high level of stability as well as resistance to enzymatic degradation. Conclusion Genipin is a promising substitute for conventional synthetic crosslinking agents, which has offered an alternative for modification of natural biomaterials for tissue engineering.

关 键 词：京尼平 交联剂 生物材料 组织工程 

分 类 号：R318.08[医药卫生—生物医学工程]