病毒感染引发天然免疫细胞信号转导研究进展  

Innate Immune Detection and Activation to Viral Infection

作　　者：孙文香[1] 蒋争凡[1] 

机构地区：[1]北京大学生命科学学院蛋白质与植物基因研究国家重点实验室,北京100871

出　　处：《中国细胞生物学学报》2013年第5期563-573,共11页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:31230023;31025010)资助的课题~~

摘　　要：病毒入侵机体后,会被天然免疫系统所识别,进而引发天然免疫信号通路的活化产生一型干扰素(IFNα/β)和一些炎性细胞因子如IL-1β。目前研究发现,病毒入侵信号主要由一类模式识别受体识别,包括Toll样受体(Toll like receptors,TLRs)、RIG-I样受体(RIG-I like receptors,RLRs)、Nod样受体(Nod like receptors,NLRs)、Hin-200家族蛋白及一些DNA受体,这些受体介导一型干扰素及炎性细胞因子的产生,并受到多种严格的调控机制调控。该文将对模式识别受体介导的抗病毒天然免疫信号转导通路及相关调控分子机制做一综述。Abstract Viral infections are detected by the innate immune system, which sequentially activates downstream signaling pathways, resulting to the production of type-I interferons （e.g IFNa/1β） and many other inflammatory cytokines （e.g TNFa, IL-land IL-18）. Viral detecting is mediated by a set of receptors called germline- encoded pattern-recognition receptors （PRRs）, including Toll-like receptors, RIG-I like receptors, Nod-like receptors, Hin-200 family proteins and some cytoplasmic DNA receptors. Activation of these PRRs will lead to the activation of different signaling pathways, which are all strictly regulated through various protein modifications. In this review, we focus on the current understanding of the antiviral innate immune activation and the related regulating mechanism.

关 键 词：天然免疫 抗病毒 细胞信号转导 一型干扰素 

分 类 号：R392[医药卫生—免疫学]