77例抗感染药物静脉滴注引起不良反应/事件分析  

Analysis of 77 Cases of Adverse Drug Reaction/Event Caused by Anti-infection Drugs Infusion

作　　者：刘耀华[1] 

机构地区：[1]河南省濮阳市中医院药剂科,河南濮阳457000

出　　处：《中国药物评价》2013年第1期46-48,共3页Chinese Journal of Drug Evaluation

摘　　要：目的:分析抗感染药物静脉滴注引起不良反应/事件的各种因素,为临床安全、合理用药提供参考。方法:对我院2010年1月至2011年12月77例抗感染药物静脉滴注引起药品不良反应/病例进行统计分析。结果:77例不良事件涉及55个药物品规,发生不良反应/事件的原因涉及单次给药剂量过大、药物浓度过高、滴注速度过快、配伍不合理、患者既往药物过敏史不详等;发生不良事件最短时间为5min,用药后31～40min出现不良反应的有45例(58.4%);临床表现以皮肤及其附件损害为主。结论:抗感染药物静脉滴注时应严格按照药品说明书给药,加强药学监护,针对引起不良反应/事件的因素应采取相应的预防措施。Objective： To analyze the causes of anti-infective drugs venous transfusion reactions/events, which provide the reference for the rational use of drugs. Methods ： 77 cases of anti-infective venous transfusion adverse drug reaction/event cases were statistically analyzed of from January 2010 to December 2011 invited clinical pharmacists consultation. Results： 77 cases of adverse reactions/events involved 55 kinds of drugs. The cause of the ADR/ADE indude dosage, drug concentration drip speed and drip infusion compatibility is not reasonable, patients before drug allergy history inquiry is unknown. Occurred adverse reaction/event the shortest time for 5 minutes, and then to forty minutes have 45 cases （58. 4% ） occurred symptoms, it is adverse reaction/event the important stage. Clinical manifestations of skin and its accessories damage to give priority. Conclusion： Anti-infective drugs vein infusion should be in strict accordance with the drug instructions to medicine, clinical pharmacists should be immediate attention vein with anti-infective drugs pharmaceutical care, accord- ing to cause adverse reactions/event factors take corresponding prevention measures, reduce the incidence of aderse events infusion.

关 键 词：抗感染药物 不良反应 事件 合理用药 

分 类 号：R95[医药卫生—药学]