秘通胶囊主要成分提取工艺优化  

Optimized Extraction Technology of Major Components of Mitong Capsule

作　　者：刘颖[1] 辛博[1] 刘文丛[1] 郑毅男[1] 

机构地区：[1]吉林农业大学中药材学院,长春130118

出　　处：《吉林农业大学学报》2013年第2期229-232,共4页Journal of Jilin Agricultural University

基　　金：吉林省科技发展计划项目(YYZX201140)

摘　　要：对一种新型泻药方剂———秘通胶囊进行制备工艺优化的研究。采用正交设计试验法,通过观察乙醇体积分数、乙醇用量及提取时间对提取工艺的影响,以结合蒽醌成分含量为指标优选方中君药酒大黄的乙醇提取工艺,并以油脂含量为指标优选臣药火麻仁和当归的乙醇提取工艺。结果表明:优选得到酒大黄最佳提取工艺为以5倍量体积分数为80%的乙醇回流提取3次(提取时间分别为2,1,1 h),火麻仁和当归最佳提取工艺为4倍量体积分数为90%的乙醇回流提取3次(提取时间分别为3,2,1 h)。秘通胶囊的主要成分———酒大黄、火麻仁和当归,其提取工艺合理、可行。Preparation research on a new type of laxative prescription-Mitong capsule was conducted. The orthogonal design test was employed to optimize the extraction technology of Jiudahuang with the content of anthraquinones, Fructus Cannabis and Angelica with the content of fatty oil. The optimum extraction of Jiudabuang was 5 times the volume of 80% ethanol for 3 times （2, 1,1 h）, and the optimum extraction of Fructus Cannabis and Angelica was 4 times the volume of 90% ethanol for 3 times （3,2, 1 h）. The opti- mized extraction technology of Jiudabuang, Fructus Cannabis and Angelica was stable and efficient. It could be used for industrial production.

关 键 词：秘通胶囊 酒大黄 火麻仁 当归 蒽醌 油脂 正交设计 

分 类 号：R284.2[医药卫生—中药学]