慢性乙肝病毒携带者中医体质类型与T淋巴细胞亚群相关性研究  

Research of correlation between chronic HBV carriers′ TCM constitution types and T lymphocyte subpopulations

作　　者：王志强[1] 车念聪[1] 郭新新[1] 赵晖[1] 刘丽花 赵义德 见国繁 王冬梅 李光超[1] 

机构地区：[1]首都医科大学中医药学院,北京100069 [2]平谷区平谷镇卫生院 [3]平谷区中医医院

出　　处：《中西医结合肝病杂志》2013年第2期79-82,共4页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

基　　金：北京市中医药科技发展基金课题(No.JJT2010-06)

摘　　要：目的:探讨慢性乙肝病毒(HBV)携带者中医体质类型与T淋巴细胞亚群的相关性。方法:根据王琦教授九种体质的判定标准,选择平和质、气虚质、阳虚质和阴虚质慢性HBV携带者43例进行T淋巴细胞亚群检测,分别对T细胞亚群的百分率、绝对计数和CD4+/CD8+比值进行统计分析。结果:阳虚质者CD4+百分率较平和质有明显降低(P<0.05),CD8+百分率较平和质、气虚质、阴虚质明显升高(P<0.05、<0.05、<0.01),CD4+/CD8+比值较平和质明显降低(P<0.05);阴虚质的CD4+百分率较平和质、气虚质、阳虚质明显升高(P<0.05、<0.01、<0.01),阴虚质的CD4+绝对计数较平和质、气虚质、阳虚质明显升高(P<0.01、<0.05、<0.01),阴虚质的CD4+/CD8+比值较气虚质、阳虚质明显升高(均P<0.01);4种中医体质慢性HBV携带者CD8+绝对值计数组间比较差异无统计学意义。结论:CD4+、CD8+T细胞及CD4+/CD8+比值的差异可以在一定程度上反映不同中医体质慢性HBV携带者免疫状态,可科学地指导慢性HBV携带者临床防治。Objective：To investigate the correlation between chronic hepatic B virus （HBV） carriers＇ TCM constitution types and T-lymphocyte subpopulations. Methods： According to the criteria of nine kinds of constitutions drawed by professor WANG QI, 43 chronic HBV carriers had been selected from normal constitution, Qi-deficiency constitution, Yang-deficiency constitution and Yin-deficiency constitution, whose T-lymphocyte subpopulations were observed by statistical analysis of the percentage, absolute counts and the ratio of T cell subsets. Results： Compared with the normal constitution chronic HBV carriers, the percentage of CD4^＋ in the Yang-deficiency constitution was significantly decreased （P〈0.05） ; the percentage of CD8^＋ in the Yang-deficiency constitution chronic HBV carriers was significantly higher than those in normal constitution, Qi-deficiency constitution and Yin-deficiency constitution （P〈0.05, 〈0.05,〈0.01 ） ; compared with the normal constitution chronic HBV carriers, the ratio of CD4^＋ and CD8^＋ in the Yang-deficiency constitution was significantly decreased （P〈0.05） . The percentage of CD4^＋ in Yin-deficiency constitution chronic HBV carriers was significantly higher than those in the normal constitution, Qi-deficiency constitution and Yang-deficiency constitution （P〈0.05, 〈0.01, 〈0.01） ; and compared with the normal constitution, Qi-deficiency constitution and Yang-deficiency constitution, the absolute count of CD4^＋ in Yin-deficiency constitution chronic HBV carriers was significantly increased （P〈0.01, 〈0.05,〈0.01） . The ratio of CD4^＋ and CD8^＋ in the Yindeficiency constitution chronic HBV carriers was significantly higher than those in the Qi-deficiency constitution and Yang-defi- ciency constitution （both P 〈0.01） . But the absolute counts of CD8^＋ in the four kinds of TCM constitutions chronic HBV carriers showed no significant differences. Conclusion： The differences of the percentage, absolute count and the ratio of

关 键 词：慢性乙肝病毒携带者 T淋巴细胞亚群 气虚体质 阳虚体质 阴虚体质 免疫状态 

分 类 号：R259[医药卫生—中西医结合]