注射用甲磺酸培氟沙星制备工艺  

Preparation Process of Pefloxacin Mesylate for Injection

作　　者：卢苇 邹意琼 

机构地区：[1]西南药业股份有限公司,中国重庆400038

出　　处：《科技视界》2013年第6期171-173,共3页Science & Technology Vision

摘　　要：目的:制备优良的注射用甲磺酸培氟沙星。方法:采用正交设计试验,考察其影响因素,对工艺进行研究。结果:最佳甘露醇的量、活性炭的加入量和抗氧剂分别为0.1g/瓶、0.05%、0.01%亚硫酸氢钠和0.01%依地酸钙钠。结论:按该方法制备的注射用甲磺酸培氟沙星,完全符合质量标准。Objective： To prepare Pefloxacin Mesylatc for Injection.Method： Optimization manufacturing process of Pefloxacin Mesylate for Injection was studied by Orthogonal design.Result： The optimum extraction condition were follows ：The best amount of mannitol,amount of activated carbon and antioxygen was separately 0.1g/bottle,0.05%,0.01% sodium hydrogen sulfite and 0.01% Calcium Disodium Edetate. Conclusion： products prepared by the optimized method can fully comply with Pefloxacin Mesylate for Injection.

关 键 词：注射用甲磺酸培氟沙星 赋形剂 抗氧剂 有关物质 含量 处方 

分 类 号：TQ466.7[化学工程—制药化工]