止泻解毒汤预防伊立替康所致延迟性腹泻的临床研究  

Zhixie Jiedu Soup in Preventing Tardive Diarrhea Caused by Irinotecan

作　　者：裴俊文 孙太振 杨峰 付槟梵 

机构地区：[1]郑州大学附属肿瘤医院,河南郑州450008

出　　处：《中医学报》2013年第5期638-639,共2页Acta Chinese Medicine

基　　金：河南省基础与前沿项目(编号:092300410022);河南省医学科技攻关重点项目(编号:201001019)

摘　　要：目的:探讨止泻解毒汤预防化疗药伊立替康引起的延迟性腹泻及血液学毒性等不良反应的疗效。方法:采用止泻解毒汤辅助伊立替康化疗方案治疗36例非小细胞肺癌患者,观察患者延迟性腹泻及血液学毒性、恶心呕吐的发生率及其程度。结果:止泻解毒汤能预防伊立替康引起的延迟性腹泻,减轻其导致的血液学毒性,并能改善由其导致的恶心呕吐症状。结论:止泻解毒汤能预防伊立替康延迟性腹泻的发生及血液学毒性,提高治疗的顺应性。Objective：To discuss the effect of zhixie jiedu soup in preventing tardive diarrhea and hematologic toxicities caused by Irino- tecan. Methods：All 36 patients wern treated with zini zhixie jiedu soup and Irinotecan. Tardive diarrhea, hematologic toxicities and nau- sea and vomiting were observed. Results：Zhixie jiedu soup prevented tardive diarrhea, alleviated hematologic toxicities and improved nausea and vomiting caused by Irinotecan. Conclusion：Zhixie jiedu soup can prevent tardive diarrhea and hematologic toxicities, in- crease therapeutic compliance.

关 键 词：延迟性腹泻 止泻解毒汤 伊立替康 

分 类 号：R273[医药卫生—中西医结合]