IL-36及其与系统性红斑狼疮的研究进展  

Interleukin-36 and systemic lupus erythematosus

作　　者：陈泽璇[1] 史建强[1] 郭红卫[1] 

机构地区：[1]广东医学院附属医院皮肤科,湛江524001

出　　处：《国际皮肤性病学杂志》2013年第3期163-166,共4页International Journal of Dermatology and Venereology

摘　　要：IL-36是IL-1家族新成员，与传统IL-1家族成员具有氨基酸序列同源性及相似的信号转导途径。IL-36主要在上皮细胞、树突细胞和CD4＋T细胞中高表达，免疫调理及免疫激活作用较传统IL-1家族成员更强，提示IL-36在免疫反应中具有巨大的潜能。IL-36在SLE等自身免疫病的发病中起重要作用，提示与SLE可能存在联系，是SLE研究中有前景的分子之一。As a novel interleukin-1 （IL-1） family member, IL-36 shares homologous amino acid sequence and similar signaling pathways with classical IL-1 family cytokines. A high expression of IL-36 is mainly observed on epidermal cells, dendritic cells and CD4＋ T lymphocytes. IL-36 shows a stronger ability to regulate and activate immunoreaction than other IL-1 family cytokines, which may indicate a relatively more important role of IL-36 in immune response. Further more, it has been implied that IL-36 plays an essential role in the pathogenesis of autoimmune diseases such as systemic lupus erythematosus. Therefore, IL-36 may be a promising molecule for future research into systemic lupus erythematosus.

关 键 词：红斑狼疮 系统性 自身免疫 白细胞介素36 

分 类 号：R593.241[医药卫生—内科学]