药物诱发加重银屑病的研究进展  

Drugs associated with the aggravation/induction of psoriasis： an update

作　　者：张冉[1] 杨森[1] 张学军[1] 

机构地区：[1]安徽医科大学皮肤病研究所安徽医科大学第一附属医院皮肤性病科,合肥230032

出　　处：《国际皮肤性病学杂志》2013年第3期169-172,共4页International Journal of Dermatology and Venereology

摘　　要：银屑病是遗传、免疫和环境因素共同作用的结果，药物作为外因之一可诱发健康人群患病或恶化病情，如β肾上腺能受体阻滞剂、锂盐、抗疟药、四环素类抗生素等。药物按其与银屑病相关程度不同，可分为明确相关，有确切证据；可能相关，缺乏确切证据；偶有报道，有争议。按其后果不同可分为诱发银屑病的药物和恶化银屑病的药物。近年来发现诱发和加重银屑病的药物种类逐渐增多，有的药物本身可用于银屑病的临床治疗。了解这些药物的致病概况及致病机制，不仅有利于预防银屑病复发，而且对临床治疗有重要的指导意义。Psoriasis is caused by a variety of internal and external paradoxical factors including genetics, immunity and environment. Drugs, such as 13-adrenergic receptor blockers, lithium, synthetic antimalarial drugs and tetracyclines, are an important external factor and can induce/aggravate psoriasis. In view of their relationship to psoriasis, drugs can be classified into agents with evident relationship supported by strong evidence, agents with potential association supported by insufficient evidence, and agents with controversial relationship supported by occasional reports. According to their effects, drugs may be classified into inducing agents and exacerbating agents. Recently, more and more drugs have been found to be associated with the induction/aggravation of psoriasis, and some of them are used in the treatment of psoriasis. Understanding the effect and pathogenic mechanisms of the associated drugs not only helps to prevent psoriasis relapse, but also is beneficial to the treatment of psoriasis.

关 键 词：银屑病 药用制剂 诱因 

分 类 号：R758[医药卫生—皮肤病学与性病学]