箬叶多糖抗肿瘤及调节免疫作用研究  

Anti-tumor and Immunoregulatory Activities of Indocalamus tessellatus Polysaccharides on the Tumor-bearing Mice

作　　者：王恩军[1] 季文琦[1] 范林林[2] 胡亚楠[2] 靳祎[1] 郭晓军[3] 李术娜[3] 

机构地区：[1]河北大学基础医学院药理系,保定071000 [2]河北省保定市儿童医院儿外科,071000 [3]河北农业大学生命科学学院生物制药系,保定071000

出　　处：《医药导报》2013年第5期586-589,共4页Herald of Medicine

基　　金：河北省人口和计划生育委员会科研计划项目(2010-A06);保定市科技局科学技术研究与发展计划项目(09ZF004)

摘　　要：目的观察箬叶多糖的抗肿瘤作用及调节免疫机制。方法以TA2荷瘤小鼠为实验模型,设肿瘤模型组、阳性对照组(环磷酰胺20 mg·kg-1)、箬叶多糖高剂量组(60 mg·kg-1)、箬叶多糖中剂量组(30 mg·kg-1)、箬叶多糖低剂量组(15 mg·kg-1)及箬叶多糖中剂量(30 mg·kg-1)联合环磷酰胺(20 mg·kg-1)组,测定箬叶多糖体内抗癌活性和小鼠脾脏指数、淋巴细胞转化能力、小鼠血清白细胞介素2(IL-2)含量等。结果箬叶多糖组及箬叶多糖联合环磷酰胺组小鼠存活时间延长,脾指数增加(P<0.05),淋巴细胞转化升高,血清IL-2含量升高。结论箬叶多糖对移植性乳腺癌有一定抑制活性,能增强荷瘤小鼠机体免疫功能,与环磷酰胺合用有增效减毒作用。Objective To explore the inhibitory action and its immunoregulatory mechamsm oi lnctocatamus tessettatus polysaeeharides on the transplantable mammary cancer mice. Methods Three different doses （60,30 and 15 mg·kg^-1 ） of Indocalrtmus tessellatus polysaecharides and the medium dose combining with eyclophosphamide were given to TA2 tumor-bearing model mice in treatment groups, respectively. The index of spleen, lymphocyte transformation and the level of serum IL-2 were determined. Results The index of spleen, lymphocyte stimulation, and IL-2 in serumwere significantly increased. Conclusion lndocalamus tesseUatus polysaccharides display inhibitory action on the mice with transplantable mammary cancer and enhance their immune functions, lndocalamus tessellatus polysaccharides combined with CTX show more efficacy and less toxicity.

关 键 词：箬叶多糖 环磷酰胺 乳腺癌 免疫调节 

分 类 号：R286[医药卫生—中药学] R965[医药卫生—中医学]