磷酸肌酸对糖尿病大鼠心肌缺血再灌注损伤心功能的影响  

Effects of phosphocreatine on cardiac function following myocardial ischemia-reperfusion injury in diabetic rats

作　　者：党旭云[1] 景桂霞[2] 常建华[2] 

机构地区：[1]西安医学院附属医院,陕西西安710077 [2]西安交通大学医学院第一附属医院,陕西西安710061

出　　处：《西安交通大学学报（医学版）》2013年第3期353-356,共4页Journal of Xi’an Jiaotong University（Medical Sciences）

摘　　要：目的探讨磷酸肌酸(PCr)对糖尿病大鼠心肌缺血再灌注损伤(MIRI)心功能的影响。方法建立糖尿病8周大鼠模型,随机分为4组:假手术组(Ⅰ)、MIRI+生理盐水组(Ⅱ)、MIRI+PCr单次注射组(Ⅲ)、MIRI+PCr多次注射组(Ⅳ),测定各组的左室收缩压(LVSP)、左室压上升最大速率(+dp/dtmax)、左室压下降最大速率(-dp/dtmax)和左室舒张末压(LVEDP)来评价心功能的变化。结果与Ⅰ组相比,Ⅱ、Ⅲ、Ⅳ组的LVSP和+dp/dtmax均呈下降趋势,Ⅱ组数值下降明显(P<0.01),Ⅲ、Ⅳ组数值下降较缓(P<0.05);与Ⅱ组相比,Ⅲ、Ⅳ组数值较大(P<0.05);Ⅲ组和Ⅳ组比较无统计学差异(P>0.05)。与Ⅰ组相比,Ⅱ、Ⅲ、Ⅳ组dp/dtmax和LVEDP均呈上升趋势,Ⅱ组上升明显(P<0.01),Ⅲ、Ⅳ组上升较缓(P<0.05);与Ⅱ组相比,Ⅲ、Ⅳ组数值均较小(P<0.05);且Ⅲ、Ⅳ组之间也有差异(P<0.05)。结论 PCr能够改善糖尿病大鼠MIRI的心功能,多次给药作用更优。Objective To investigate the effects of phosphocreatine （PCr） on cardiac function following myocardial ischemia-reperfusion injury （MIRI） in diabetic rats. Methods The rat models of diabetes mellitus （DM） for eight weeks were induced. The diabetic rats were randomly divided into four groups： sham-operation group （ I ）; MIRI＋saline group （Ⅱ）; MIRI-LPCr administered for a single dose （Ⅲ）; and MIRI＋ PCr administered for multiple doses （Ⅳ）. The hemodynamic parameters such as LVSP, Tdp/dtmax, -dp/dtmax and LVEDP were recorded to evaluate the cardiac function. Results Compared with those in Group I , LVSP and -Fdp/dtmax in the other three groups decreased; they decreased obviously in Group Ⅱ （P〈0.01）, and then in Group Ⅲ and 1V （P〈0.05）. The two indicators were significantly higher at each time point in Group Ⅲ and Group IV than in Group Ⅱ （P〈0.05）; there were no significant differences between the latter two groups （P〉0.05）. Compared with Group I , the values of --dp/dtmax and LVEDP in the other three groups showed an upward trend; they increased markedly in Group Ⅱ （P〈0.01） and increased mildly in Groups Ⅲ and IV （P〈0.05）. The two indicators were significantly lower in Group Ⅲand IV than in Group Ⅱ （P〈0.05） ; the former two groups differed significantly （P〈0.05）. Oonclusion The precondition of PCr can improve the cardiac function of diabetic rats after ischemia-reperfusion injury. PCr administered for multiple doses is more effective than a single dose.

关 键 词：磷酸肌酸 糖尿病大鼠 心肌缺血再灌注损伤 心功能 

分 类 号：R587.1[医药卫生—内分泌]