不同类型羟基磷灰石义眼台的纤维血管化程度  

Fibrovascularization of different types of hydroxyapatite orbital implants

作　　者：王星力[1] 刘鹤南[1] 陈晓隆[1] 

机构地区：[1]中国医科大学附属盛京医院眼科,辽宁省沈阳市110004

出　　处：《中国组织工程研究》2013年第12期2265-2272,共8页Chinese Journal of Tissue Engineering Research

摘　　要：背景:羟基磷灰石义眼台是目前最理想的眼内填充植入物,具有广泛的应用前景。目的:评价不同类型羟基磷灰石义眼台的纤维血管化程度。方法:应用放射性核素、MRI成像和组织病理学检测的方法,评价孔径大小不同的天然羟基磷灰石义眼台以及人工合成羟基磷灰石义眼台的纤维血管化程度,并分析碱性成纤维细胞生长因子胶原蛋白对羟基磷灰石义眼台促纤维血管化的作用。结果与结论:放射性核素显像、MRI成像以及组织病理学检测均能够清晰显示羟基磷灰石义眼台纤维血管化的过程和程度,一般需要6-8周完成血管化,天然羟基磷灰石义眼台纤维血管化的速度快于人工合成羟基磷灰石义眼台,并且孔径越大的义眼台,其血管化的速度越快。碱性成纤维细胞生长因子对羟基磷灰石义眼台有促进血管化的作用,可加快羟基磷灰石义眼台血管化的速度。BACKGROUND： Hydroxyapatite orbital implant is the best intraocular implant which has broad application prospects. OBJECTIVE： To evaluate the degree of fibrovascularization of different types of hydroxyapatite orbital. METHODS： The fibrovascularization degree of natural hydroxyapatite orbital implants with different pore sizes and synthetic hydroxyapatite orbital implants was evaluated with radionuclide, MRI imaging and histopathological examination, and the effect of basic fibroblast growth factor col agen on the fibrovascularization of hydroxyapatite orbital implants was analyzed. RESULTS AND CONCLUSION： Radionuclide, MRI imaging and histopathological examination could clearly display the process and degree of fibrovascularization of hydroxyapatite orbital, and the examination results showed that the vascularization could be completed general y in 6-8 weeks, and the speed of fibrovascularization of natural hydroxyapatite orbital was faster than that of synthetic hydroxyapatite orbital, and there was positive correlation between the pore size and the speed of fibrovascularization. Basic fibroblast growth factor could promote the vascularization of hydroxyapatite orbital.

关 键 词：生物材料 生物材料学术探讨 羟基磷灰石 义眼台 纤维血管化 胶原蛋白 碱性成纤维细胞生长因子 放射性核素 组织病理学 MRI CT 

分 类 号：R318[医药卫生—生物医学工程]