皮贴雌激素在不孕症治疗中的应用  

Application of Fem-7 patch in the diagnosis and treatment of infertility

作　　者：张荣环 张令浩[2] 宋坚红[3] 孙大文 顾一村 

机构地区：[1]上海市天伦医院妇产科,上海200434 [2]第二军医大学长征医院妇产科,上海200003 [3]上海市杨浦区中心医院妇产科,上海200090 [4]上海市卢湾区中心医院妇产科,上海200020 [5]上海市黄浦区中心医院妇产科,上海200002

出　　处：《上海医药》2013年第9期29-31,43,共4页Shanghai Medical & Pharmaceutical Journal

摘　　要：目的:探讨皮贴雌激素在不孕症治疗中的应用。方法:入选诊断为不孕症需用外源性雌激素的患者,排除外输卵管等其他因素所致不孕症及不适合用药的疾病。应用皮贴雌激素进行治疗,观察用药前后宫颈黏液Insler评分及子宫内膜厚度的变化,并对应用CC/HMG患者加快卵泡发育的影响,用阴超监测子宫内膜厚度和卵泡大小,测定体内雌激素水平的变化,以及受孕情况。结果:应用皮贴雌激素3～4h即可达到有效的血浆浓度并保持在这个水平达7d之久,改善宫颈黏液性状、量增加变稀薄,拉丝度增加,子宫内膜增厚,促进卵泡发育成熟,妊娠率增加。结论:皮贴雌激素可改善宫颈黏液的性状,促进子宫内膜的生长,促进卵泡的发育并增加妊娠率,提示其可应用于生殖医学尤其是不孕症的治疗中。to investigate the improvement and adjustment of conception factor of barrenness patients who have applied Fem 7 estradiol patch, and to promote the clinical observation of conception effect. Methods： Eight hundred and ninety eight cases who are diagnosed as barrenness and need exogenous estrogen are selected. The patients, for whom other incompetent diseases are excluded, accept therapy as request. The changes of cervical mucus （CM）, endometria and the effect of HMG on follicular development before and after medication are observed. The endometria thickness, egg follicle size, the changes of estrogen level and ultimate conception are detected. Results： The effective plasma concentration can be reached within 3-4 hours after application of Fem 7 patch and retained for 7days. Conclusion： The application of Fem 7 patch in the barrenness of generation medicine can improve the quality of cervical mucus, promote the growth of endometria, accelerate follicular development and increase pregnancy rate.

关 键 词：松奇 皮贴雌激素 不孕症 妊娠率 

分 类 号：R711.6[医药卫生—妇产科学]