血脂平稳度对兔动脉粥样硬化病变进展的影响  

Effect of lipid smoothness on progression of atherosclerosis in rabbits

作　　者：邹晓[1] 司全金[1] 蔡力力[2] 

机构地区：[1]解放军总医院南楼心血管一科,北京100853 [2]解放军总医院南楼临床检验科,北京100853

出　　处：《解放军医学院学报》2013年第5期509-512,共4页Academic Journal of Chinese PLA Medical School

摘　　要：目的探讨血脂平稳度对兔动脉粥样硬化病变进展的影响。方法 24只雄性新西兰大耳兔随机分为3组,空白组(A)6只,对照组(B)9只,血脂波动组(C)9只,A组给予普通饲料,B组持续高脂饲料喂养,C组高脂饲料喂养至12周后与低脂饲料每隔3周交替喂养1次,共喂养24周。分别于0周、12周更换高低脂饲料时测定血脂及hs-CRP水平,并行腹主动脉超声检查。观察主动脉病理学改变并分析病变程度。结果 12周时,血清TC、TG、LDL-C及hs-CRP水平,B组分别为(37.36±1.82)mmol/L、(2.30±1.46)mmol/L、(40.33±2.32)mmol/L、(0.40±0.10)mg/dl,C组为(34.96±6.98)mmol/L、(1.48±0.82)mmol/L、(34.65±7.94)mmol/L、(0.45±0.11)mg/dl,均较A组(0.78±0.24)mmol/L、(0.61±0.44)mmol/L、(0.27±0.13)mmol/L、(0.17±0.04)mg/dl显著升高(P<0.01)。24周时,C组TC、LDL-C的SI值(3.60、3.29)明显低于B组(12.51、7.61),B、C组血清TC、TG、LDL-C、hs-CRP水平升高的同时,C组hs-CRP水平(0.53±0.07)mg/dl较B组(0.45±0.06)mg/dl升高(P<0.05)。12周时B、C组腹主动脉内-中膜厚度(intima-media thickness,IMT)(0.70±0.11、0.84±0.14)mm均高于A组(0.40±0.01)mm,24周时C组IMT(1.10±0.21)mm高于B组(0.77±0.11)mm。B、C组主动脉内膜可见典型动脉粥样斑块,C组斑块面积百分比(53.53±22.6)%较B组(33.90±24.91)%高,但斑块纤维帽厚度(103.50±45.66)μm较B组(295.83±97.90)μm薄(P<0.01),光镜下可见纤维帽不连续。结论血脂平稳度与动脉粥样硬化病变的进展相关,血脂平稳指数越小斑块发展速度越快,其发生机制可能与炎症反应加重有关。Objective To study the effect of lipid smoothness on progression of atherosclerosis in rabbits.Methods Twenty-four male New Zealand rabbits were randomly divided into blank group（group A,n=6）,control group（group B,n=9）,and lipid fluctuation group（group C,n=9）,and fed with normal diet,continuous high fat diet,and high fat diet,respectively,for 12 weeks,followed by low-fat diet every 3 weeks for 24 weeks.Their serum lipid and hs-CRP levels were measured at weeks 0 and 12 when the high fat diet was changed.The abdominal aorta was examined by ultrasonography.Pathologic changes of aorta were observed and their severity was analyzed.Results The serum levels of TC,TG,LDL-C and hs-CRP were significantly higher in groups B and C than in group A at week 12（（37.36±1.82） mmol/L,（2.30±1.46） mmol/L,（40.33±2.32） mmol/L,（0.40±0.10） mg/dl and（34.96±6.98） mmol/L,（1.48±0.82） mmol/L,（34.65±7.94） mmol/L,（0.45±0.11） mg/dl vs（0.78±0.24） mmol/L,（0.61±0.44） mmol/L,（0.27±0.13） mmol/L,（0.17±0.04） mg/dl,P0.01）.The lipid smoothness index（SI） of TC and LDL-C was significantly lower in group C than in group B（12.51 and 7.61 vs 3.60 and 3.29,P0.05） while the serum levels of TC,TG,LDL-C and hs-CRP were higher in both groups B and C, and the serum hs-CRP level was significantly higher in group C than in group B at week 24（（0.53±0.07） mg/dl vs（0.45±0.06）mg/dl, P0.05）.The IMT of abdominal aorta was significantly greater in groups B and C than in group A at week 12（（0.70±0.11） mm and（0.84±0.14） mm vs（0.40±0.01） mm,P0.05） and in group C than in group B at week 24（（1.10±0.21） mm vs（0.77±0.11） mm, P0.05）.The incidence of endoaortic atherosclerotic plaques was significantly higher in group C than in group B（53.53%±22.6% vs 33.90%±24.91%,P0.05）.However,the plaques in fibrous cap were thinner in group C than in group B（（103.50±45.66） μm vs（295.83±97.90） μm,P0.01）.Discontinuous fibrous cap could be observe

关 键 词：动脉粥样硬化 血脂平稳度 兔 

分 类 号：R541.4[医药卫生—心血管疾病]