小鼠急性胰腺炎时Hedgehog信号通路mRNA的表达及意义  

The role of Hedgehog signal in mice with acute pancreatitis

作　　者：黄娟[1] 郑英强[2] 周翔宇[2] 

机构地区：[1]泸州医学院病理学教研室 [2]泸州医学院附属医院血管和甲状腺外科,四川泸州646000

出　　处：《泸州医学院学报》2013年第2期121-123,共3页Journal of Luzhou Medical College

基　　金：国家自然科学基金项目(81100272);四川省教育厅科研基金项目(10ZB120)

摘　　要：目的:探讨小鼠急性胰腺炎时Hedgehog信号通路的作用。方法:雨蛙素腹腔注射诱导小鼠急性胰腺炎模型,用RT-PCR方法检测Hedgehog信号通路各基因在胰腺组织的表达。结果:与对照组相比较,雨蛙素注射1h后,Shh、Ptch1、Gli2表达逐渐升高,在24h,到达最高。结论:在急性胰腺炎症过程中,Hedgehog信号通路可能参与调节组织修复和细胞的增生。Objective：To study the potential role of hedgehog signal axis in mice with acute panereatitis. Methods：Acute panereatitis model was induced by intraperitoneal injection of cerulean 7 times hourly in mice. Hedgehog signal expression was detected by real-time reverse transcription-polymerase chain reaction （RT-PCR）. Results：Compared with control group, Shh and Gli2 in experimental group increased gradually, up to peak value at 24h. Conclusion： Shh/Gli2 signal axis may be involved in the regulation of tissue repair and cell proliferation during the course of mice with acute panereatitis.

关 键 词：HEDGEHOG SHH GLI2 急性胰腺炎 

分 类 号：Q522.2[生物学—生物化学]