PHA-767491抑制肝癌细胞生长的研究  

Study on Inhibition of Hepatoma Carcinoma Cell Growth by PHA-767491

作　　者：李伟[1] 尚世强[1] 楼金吐[1] 陈黎勤[1] 李仲杰[2] 魏旭斌[3] 

机构地区：[1]浙江大学医学院附属儿童医院中心实验室,杭州310003 [2]浙江大学医学院,杭州310052 [3]浙江理工大学生命科学院,杭州310018

出　　处：《浙江理工大学学报（自然科学版）》2013年第3期364-366,共3页Journal of Zhejiang Sci-Tech University(Natural Sciences)

基　　金：浙江省自然科学基金项目(Y2100891);浙江省"生物医学工程"重中之重学科开发基金(SWYX0917)

摘　　要：利用不同浓度的PHA-767491对多种肝癌细胞株进行杀伤研究,探讨PHA-767491对肝癌细胞的抑杀作用。MTT实验结果表明,PHA-767491能显著抑制多种肝癌细胞株的增殖。Hoechst 33342染色结果也表明PHA-767491可以诱导肝癌细胞进入凋亡。表明PHA-767491对肝癌细胞具有较高的杀伤作用,可能具有广阔的应用前景。This paper studies the killing ability of PHA-767491 with different concentrations for multiple hepatoma carcinoma cell lines and discusses the inhibition function of PHA-767491 for hepatoma carcinoma cell. MTT experimental result shows that PHA-767491 can significantly inhibit the proliferation of multiple hepatoma carcinoma cell lines. Hoechst33342 dyeing results show that PHA-767491 can induce apoptosis of hepatoma carcinoma cell. Therefore, the result of this research indicates that PHA-767491 has a high killing ability for hepatoma carcinoma cell and might have a wide application prospect.

关 键 词：PHA-767491 肝癌细胞 凋亡 

分 类 号：Q279[生物学—细胞生物学]