无痛人流术对患者Th1/Th2细胞因子平衡的影响  

Influence of painless abortion surgery on Th1/Th2 cytokine balance

作　　者：黄丽[1] 王开林[1] 

机构地区：[1]昆山市第四人民医院妇产科,江苏昆山215331

出　　处：《海南医学院学报》2013年第5期658-660,共3页Journal of Hainan Medical University

基　　金：昆山市科技计划项目(KS0926)~~

摘　　要：目的:观察无痛人流术患者血浆Th1/Th2细胞因子的变化,评价麻醉下人工流产术对患者应激反应及免疫功能的影响。方法:选择做人工流产手术患者60例,随机分为2组,无痛人流组(A组)和普通人流组(B组),每组各30例,分别于开始手术前(T1)、扩宫口时(T2)、手术结束后30min(T3)三个时点,在患者非输液侧前臂采集静脉血2mL,采用ELASA法测定血浆IFN-γ和IL-10浓度。结果:丙泊酚-芬太尼静脉麻醉用于人工流产手术患者IFN-γ和IL-10浓度变化不大,而无麻醉组IFN-γ浓度显著降低,IL-10浓度显著升高。结论:无痛人流术减少了患者的痛苦,术中便于操作,缩短了手术时间,预防人工流产综合征的发生,降低了病人因手术刺激引起的血浆IFN-γ和IL-10变化,有效抑制应激反应,保护机体免疫功能。Objective： To observe the influence of painless abortion surgery on Thl/Th2 cytokine balance and to evaluate the influence of artificial abortion under anesthesia on stress response and immune function. Methods. Sixty patients scheduled for artificial abortion were randomly divided into painless abortion group （group A） and routine abortion group （B）, with 30 cases in each group. At three time points including, before the surgery （T1）, time for expansion of cervix （（T2） and 30 rain after the end of surgery （T3）, collect 2 mL non-transfusion blood from the forearm of patients for IFN-γ, and IL-10 concentration determination by ELASA method. Results： Group A which underwent surgery under anesthesia with fentanyl and propofol showed little change in IFN-γ and IL-10 concentration, but in group B, IFN-γ concentration significantly decreased and IL-10 concentration significantly increased. Conclusion. Painless abortion is less time consuming but more comfortable than routine abortion surgery, it induce less complications and has less influence on IFN-γ and IL-10 concentrations, can effectively inhibit stress response to protect the body＇s immune function.

关 键 词：无痛人流术 IFN-Γ IL-10 

分 类 号：R719[医药卫生—妇产科学]