对羟基苯乙腈的新合成方法研究  

New Synthesis of 4-hydroxybenzyl Cyanide

作　　者：祝兴龙[1] 周贻森[1] 朱林晓[1] 王明[1] 吴斌飞[1] 宗乾收[2] 

机构地区：[1]嘉兴学院南湖学院,浙江嘉兴314001 [2]嘉兴学院生物与化学工程学院,浙江嘉兴314001

出　　处：《嘉兴学院学报》2013年第3期78-81,共4页Journal of Jiaxing University

基　　金：浙江省大学生科研创新团队资助项目(2012R417001);嘉兴市科技局资助项目(2013R516080)

摘　　要：研究了对羟基苯乙酰胺在甲苯为溶剂和二丁基氧化锡为催化剂下发生脱水反应制备对羟基苯乙腈.通过改变催化剂用量、反应温度、反应时间和溶剂用量等因素研究对羟基苯乙腈的最佳制备工艺条件:二丁基氧化锡用量为对羟基苯乙酰胺的1.5%(按质量计算)、反应温度为110℃、反应时间为12h、甲苯用量为对羟基苯乙酰胺的6倍(按质量计算).同时得出,最佳工艺条件下,对羟基苯乙腈的收率为95.3%.并通过熔点、核磁氢谱及红外光谱对新产品进行了结构表征.4-hydroxybenzyl cyanide was synthesized from 4-hydroxybenzeneacetamide in toluene by dehy dration reaction using Bu2 SnO as the catalyst. The influences of the quantity of Bu2 SnO, the reaction temperature, the reaction time and the quantity of tolueno on the yield of 4-hydroxybenzyl cyanide were investigated. The optimum reaction conditions were： Bu2 SnO being 15 percent of 4-hydroxybenzeneacetamide by mass, reaction temperature 110℃, reaction time 12 h and toluene six times of 4-hydroxybenzeneacetamide by mass. Under the optimum conditions, the yield of e4- hydroxybenzyl cyanide was 95.3%. In addition, the product was characterized by melting point,IR and ^1 H NMR spectrometry.

关 键 词：对羟基苯乙酰胺 二丁基氧化锡 对羟基苯乙腈 脱水 

分 类 号：O621.3[理学—有机化学]