婴幼儿巨细胞病毒性肝炎应用更昔洛韦的效果评价  

Evaluate Effect of Using Ganciclovir to Treat Infant Cytomegalovirus Hepatitis

作　　者：卢立党[1] 郭爱红[1] 柳会琼 

机构地区：[1]浙江省苍南县人民医院,浙江苍南325800

出　　处：《儿科药学杂志》2013年第5期17-19,共3页Journal of Pediatric Pharmacy

摘　　要：目的:观察婴幼儿巨细胞病毒性肝炎患儿应用更昔洛韦治疗的临床效果。方法:选取我院收治的60例患有巨细胞病毒性肝炎的婴幼儿,按照随机数字表法分为试验组和安慰剂组,每组30例。试验组给予更昔洛韦治疗,分为诱导期及维持期治疗。诱导期给予更昔洛韦5 mg/kg加入10%葡萄糖注射液100 mL中静脉滴注,每日2次,诱导期疗程为14 d;后进入维持期治疗,应用更昔洛韦5 mg/kg加入10%葡萄糖注射液100 mL中,每日1次静脉滴注,疗程14 d。安慰剂组给予形态、外观与试验组一致的安慰剂药物。分析比较使用更昔洛韦治疗前后患儿的症状及各项临床生化指标检查结果。结果:治疗后所有患儿临床症状均显著改善;安慰剂组患儿CMV-IgM转阴率为56.67%,试验组为83.33%,两组比较差异有统计学意义(P<0.05);试验组较安慰剂组患儿的谷丙转氨酶(GPT)及总胆红素(TBIL)显著降低(P<0.05);治疗过程中不良反应轻微。结论:更昔洛韦治疗婴幼儿巨细胞病毒性肝炎安全有效。Objective： To observe and discuss clinical effect of using ganciclovir to treat infant cytomegalovirus hepatitis. Methods： To observe 60 cases of infant patients with cytomegalovirus hepatitis admitted in our hospital, all patients included in the study were divided into the test group and the placebo group according to the random number table, each group included 30 cases. The test group received ganciclovir treatment, divided into induction period and maintenance phase. During the induction period, all infant patients was given 5 mg/kg ganciclovir which added into 100 mL of 10% glucose injection, twice a day, treatment for 14 days; after entering the maintenance phase, ganciclovir 5 mg/kg into 100 mL of 10% glucose injection, once a day, the treatment is the same for 14 days. The placebo group was given placebo medication not only shape but appearance which was same as the test group. To compare and analyze the patientse＇ symptoms of the use of ganciclovir treatment before and after and relevant laboratory tests results. Results： After treatment, clinical symptoms with all infant patients significantly improved; the treatment rate of the placebo group was 56.67%, the treatment rate of the test group was 83.33% （P〈0.05）, the differences between the two groups was statistically significant. Glutamic- pyruvic transaminase （GPT） and total bilirubin （TBIL） of the test group was significantly lower than the placebo group （P〈0.05）; adverse reactions were mild in treatment. Conclusions： In treatment of infants cytomegalovirus hepatitis, ganciclovir was safe and effective.

关 键 词：婴幼儿 巨细胞病毒 肝炎 更昔洛韦 

分 类 号：R725.7[医药卫生—儿科]