几种化合物改变纤维海泡石对红细胞毒性初探  

Modification of RBC Toxicity of Fibrous Sepiolite by Several Substances

作　　者：邓建军[1] 董发勤[2] 吴逢春[1] 李国武[2] 赵世泉[1] 庄稼[2] 

机构地区：[1]四川省绵阳市第四人民医院,绵阳621000 [2]西南工学院,绵阳621002

出　　处：《岩石矿物学杂志》2000年第3期254-257,共4页Acta Petrologica et Mineralogica

基　　金：国家自然科学基金项目!(编号 :4 950 2 0 2 5)资助

摘　　要：纤维海泡石对红细胞有毒性。本文采用阳离子交换、Gamble溶液、有机酸及尼古丁处理纤维海泡石 ,观察处理前后红细胞的溶血率及脂质过氧化的主要产物丙二醛 (MDA)的变化。结果显示 :经过阳离子交换及Gamble溶液处理 ,纤维海泡石对红细胞的毒性显著降低 ,其机制可能是延长了界 /膜形成时间 ,降低了脂质过氧化的强度 ;有毒物质 ,如尼古丁的参与则增强了海泡石对红细胞的毒性 ;有机酸处理对红细胞的毒性影响不明显。Fibrous sepiolite has cytotoxicity to human erythrocyte. In order to evaluate the hemolysis of fibrous sepiolite from Guangji of Hubei Province, the fibrous sepiolite was treated by cation exchange, Gamble solution, organic acid and nicotine, and then the changes of the percentage of hemolysis and malandialdehyde (MDA)——the main product of superoxidation of lipids——before and after the treatment were observed. The results indicate the following: the RBC toxicity of fibrous sepiolite treated by cation exchange and Gamble solution decreases significantly and its possible mechanism is to decrease the intensity of lipid superoxidation and prolong the time of surface/membrane formation; the RBC toxicity of fibrous sepiolite increases significantly in the presence of nicotine; while fibrous sepiolite treated by organic acid has insignificant effect on human erythrocyte.

关 键 词：纤维海泡石 阳离子交换 粉尘 红细胞 毒性 

分 类 号：R135.2[医药卫生—劳动卫生]