乙型肝炎病毒前C区1896点突变及临床意义  

Detection of nt1896 point mutation in HBV precore region and clinical significance

作　　者：谢晨[1] 肖萍[2] 陈青锋[2] 郭振华[2] 

机构地区：[1]大连医科大学附属二院传染科,大连116027 [2]兰州医学院附属一院传染科,甘肃兰州730000

出　　处：《临床肝胆病杂志》2000年第3期148-149,共2页Journal of Clinical Hepatology

摘　　要：为了解兰州地区HBV前c区1896位点突变的存在及临床意义，我们对86例乙肝抗体阳性而抗原阴性慢乙肝患者进行了错配PCR限制片段长度多态性分析（ｍｐ－ＰＣＲ－ＲＦＬＰ）。结果显示ＨＢＶ　ＤＮＡ阳性２４．４２％（２１／８６），变异者１９．０５％（４／2１）。说明体内ＨＢＶ并未完全清除，兰州地区存在ＨＢＶ前ｃ区1896位点突变且与病情似有一定关系。To investigate mutation in HBV precore region of HBV and its clinical significance,we detected 86 cases of chronic Hepatitis B HBV patients from Lanzhou area They were all HBV antibodies positive and antigenes negative Mp-PCR-RFLP was used to detect nt 1896 point mutation in HBV precore region the results showed that 24.42%(21/86) were HBV DNA positive and 19.05%(4/21) of patients with HBV DNA positive of patients with HBV DNA positive has mutant HBV infection.It is showed that HBV is existence in the patients and the mutation is existence in Lanzhou area Perhaps it is relative between the mutation and the patients’s condition

关 键 词：乙型肝炎 HBV前c区1896位点突变 HBV-DNA 

分 类 号：R512.62[医药卫生—内科学]