索利那新加坦索罗辛治疗留置双“J”管后相关并发症的疗效分析  

Efficacy of Tamsulosin and Solifenacin Combined Therapy for the Treatment of Ureteral-Stent-Related Discomforts

作　　者：胡尧[1,2] 张先觉[1,2] 李又空[1,2] 曾金敏[1,2] 廖义翔[1,2] 严友纪[1,2] 

机构地区：[1]长江大学荆州临床医学院 [2]荆州市中心医院泌尿外科,湖北荆州434020

出　　处：《长江大学学报（自科版）（下旬）》2013年第4期32-34,1,共3页Journal of Yangtze University

摘　　要：目的:探讨索利那新加坦索罗辛治疗留置双"J"管后患者相关并症状的疗效。方法:136例患者被随机分为3组,A组(48例)仅给予术后常规治疗;B组(43例)术后口服索利那新0.5mg,1次/d,C组(45例)术后口服索利那新加坦索罗辛。通过问卷记录术后第1天和拔除双"J"管当日国际前列腺症状评分/生活质量评分(IPSS/QoL)和视觉模拟疼痛评分(VAPS)。结果:A组、B组和C组IPSS总评分、刺激性症状评分差异有统计学意义,A组和C组梗阻性症状评分和QoL评分差异有统计学意义,3组VAPS评分差异无统计学意义。结论:索利那新联合坦索罗辛用药改善留置双"J"型输尿管内支架管后患者相关并发症的疗效显著,优于单用索利那新组。Objective: To evaluate the efficacy and safety of solifenacin and tamsulosin in the treatment of the lower urinary tract symptoms of patients with indwelling double-J ureteral stents.Methods: A total of 48 patients received routine postoperative treatment(Group A),45 patients were given solifenacin 5 mg once daily(Group B),and 43 patients were given a combination of two agents postoperatively(Group C).International prostate symptom score/quality of life(IPSS/QOL) and visual analogue pain scale(VAPS) questionnaires were completed by each patient on the first day postoperatively and on the day of stent removal.Results: There was a significant difference in the IPSS total score,irritative score and the QOL score between group A and groups B and Group C.Group A also differed significantly from group C in the obstructive score.There were no significant differences in the VAPS.Conclusion: It is more effective and safer for patients with the lower urinary tract symptoms and with indwelling double-J ureteral stents to accept combination therapy of tamsulosin and solifenacin.

关 键 词：索利那新 坦索罗幸 双J管 输尿管内支架管相关并发症 

分 类 号：R699.4[医药卫生—泌尿科学]