山栀茶抗抑郁活性部位研究  

Study on antidepression effect of Radix Pittospori

作　　者：左晓娜[1,2] 肖炳坤[1] 刘妍如[3] 杨建云[1] 甄蓓[1] 黄荣清[1] 

机构地区：[1]军事医学科学院放射与辐射医学研究所,北京100850 [2]江西中医学院,南昌330006 [3]沈阳药科大学,沈阳110016

出　　处：《军事医学》2013年第4期283-285,共3页Military Medical Sciences

基　　金：十二五国家科技重大专项"重大新药创制"综合性新药研究开发技术大平台资助项目(2012ZX09301003-001-010);国家自然科学基金资助项目(81072613)

摘　　要：目的对山栀茶醇提物的抗抑郁活性部位进行筛选。方法通过小鼠悬尾实验、小鼠强迫游泳实验以及小鼠体质量变化,对山栀茶醇提物中石油醚、二氯甲烷、乙酸乙酯和正丁醇部位的抗抑郁活性进行筛选评价。结果山栀茶醇提物中正丁醇-高剂量组和乙酸乙酯-高、低剂量组都明显缩短小鼠悬尾不动时间(P<0.05);而正丁醇-高剂量组、乙酸乙酯-高、低剂量组可以明显缩短小鼠游泳不动时间(P<0.05),其中乙酸乙酯-高剂量组作用优于其他组(P<0.01)。结论山栀茶具有抗抑郁作用,活性成分主要分布在正丁醇和乙酸乙酯部位。Objective To evaluate the antidepressant-like activities of different extracts of Radix Pittospori（RP）.Methods The forced swimming test（FST）,tail suspension test（TST） and change in the mice body mass were used to evaluate the antidepressant-like effect of the ethanol extracts of RP.Results It was observed that n-butanol extract at high dose,or EtoAc extract at high or low doses significantly reduced the immobility time in TST while n-butanol extract at high dose,or EtoAc extract at high or low doses significantly reduced the immobility time in the FST.In addition,the EtoAc extract at high dose showed better antidepressant-like activities than other extracts.Conclusion The n-butanol extract and EtoAc extract of RP produce antidepression effect.

关 键 词：抗抑郁 强迫游泳实验 悬尾实验 

分 类 号：R284[医药卫生—中药学] R971.4[医药卫生—中医学]