志贺菌属逃避宿主固有免疫系统的机制研究进展  

Advances in research on mechanism of evasion from host innate immunity of Shigella

作　　者：杨展[1] 王思淼[1] 崔茜[1] 刘威[1] 王雪松[1] 邹大阳[1] 李雪莲[1] 李环[1] 王玉飞[1] 黄留玉[1] 袁静[1] 

机构地区：[1]军事医学科学院疾病预防控制所,北京10007

出　　处：《军事医学》2013年第4期311-314,共4页Military Medical Sciences

基　　金：国家"十二五"科技重大专项资助项目(2011ZX10004-001);国家自然科学基金资助项目(81071321)

摘　　要：肠黏膜上有多重先天免疫防御系统,当发生细菌感染时,可以向免疫系统传递信号,抵御细菌的入侵,而且使被破坏或衰老的上皮细胞再生;然而肠黏膜致病菌具有的多重致病机制可以适应宿主的炎性反应和免疫反应,能使宿主细胞死亡并操控宿主细胞存留的信号通路。这些特性使致病菌能够适应肠黏膜环境,破坏细胞功能和免疫功能,从而使致病菌对宿主的感染更易发生。本文综述了宿主对细菌感染的抵抗机制和志贺菌属逃避宿主固有免疫系统的机制。The intestinal mucosa possesses multiple innate immune defense systems which could sense bacterial infection,transmit alarm signals to the immune system,defeat intruding bacteria,and renew damaged and aged epithelial cells.Nevertheless,mucosal bacterial pathogens have versatile pathogenic mechanisms that could modulate the host inflammatory and immune responses,manipulate host cell death and survival signal pathways.These properties enable pathogens to adapt to the intestinal mucosal environment,exploit cellular and immune functions,and facilitate infection.Current studies on host defense mechanisms against bacterial infection and the countermeasures taken by Shigella to evade the innate immune system are reviewed.

关 键 词：志贺菌属 宿主 免疫系统 细菌感染 

分 类 号：R392.1[医药卫生—免疫学]