女性宫颈人乳头状瘤病毒感染及其基因型别  

Human papillomavirus causing cervical infections and its genotypes

作　　者：何静[1] 唐双阳[2] 宋小鹏 李乐[2] 

机构地区：[1]惠州市中心人民医院检验中心 [2]南华大学病原生物学研究所 [3]惠州市95140部队卫生队

出　　处：《中华医院感染学杂志》2013年第9期2015-2017,共3页Chinese Journal of Nosocomiology

基　　金：湖南省卫生厅课题(B2011-043);衡阳市课题(2011KS15)

摘　　要：目的了解医院不同年龄段女性宫颈人乳头状瘤病毒(HPV)感染状况及其分布,为HPV分子流行病学研究提供依据。方法收集2010年1月-2011年8月医院就诊的3288例宫颈刷片标本,用凯普医用核酸分子杂交系统进行HPV基因分型检测。结果 HPV总感染率为18.95%;高危型主要为HPV16占HPV阳性亚型总数的16.92%;HPV52占15.96%;HPV58占14.60%;各年龄组总HPV阳性率以及高危HPV阳性率居前3位的是30～39、40～49岁和50～59岁。结论高危型HPV亚型前3位为HPV 16、52、58;30～39岁年龄段HPV阳性率最高。OBJECTIVE To study the human papilloma virus（HPV） causing cervical infections in various age groups of female patients and observe its genotypes so as to provide scientific basis for the HPV epidemiological research.METHODS The cervical tissue specimens obtained from 3288 female patients were examined with DNA extraction and nucleic acid hybridization technique（cape medical system）.RESULTS The total HPV infection rate was 18.95%.HPV16 was the most prevalent high-risk type,accounting for 16.92% among the positive HPV genotypes,followed by HPV52（15.96%） and HPV58（14.60%）.Among the various age groups,the top three groups with the total HPV positive rate and the high risk HPV positive rate were the 30-39 age group,40-49 age group,and 50-59 age group.CONCLUSION The most prevalent high risk HPV genotypes in the female patients are HPV16,HPV52,and HPV58.The positive rate of the HPV in the 30-39 age group is the highest.

关 键 词：人乳头状瘤病毒 基因亚型 宫颈癌 

分 类 号：R373[医药卫生—病原生物学]