2型糖尿病患者生活质量和抑郁状态与其低血糖反应的关系研究  

Impact of Quality of Life and Depression on Hypoglycemia in Patients with Type 2 Diabetes Mellitus

作　　者：涂传发 王丽君[1] 金都[1] 张幽幽[1] 杨宏伟[1] 

机构地区：[1]浙江省台州市第一人民医院内分泌代谢科,318020

出　　处：《中国全科医学》2013年第10期1113-1114,1119,共3页Chinese General Practice

摘　　要：目的探讨2型糖尿病(T2DM)患者生活质量和抑郁状态与其低血糖反应的关系。方法根据既往半年内是否发生低血糖反应分为低血糖组和非低血糖组。首先单因素分析低血糖组和非低血糖组生活质量评分、抑郁状态评分、空腹血糖、糖化血红蛋白和体质指数的差别,然后以单因素分析有统计学意义的变量为自变量进行多元回归分析,探讨低血糖的危险因素。结果 (1)低血糖组体质指数高于非低血糖组〔(24.8±1.9)kg/m2比(24.2±1.8)kg/m2〕,差异有统计学意义(P<0.05);(2)低血糖组躯体健康总评得分〔(301.3±30.3)分比(312.8±31.2)分〕和心理健康总评得分〔(304.0±30.8)分比(316.1±31.4)分〕均低于非低血糖组,差异有统计学意义(P<0.01);低血糖组健康问卷抑郁量表(PHQ-9)评分差于非低血糖组,差异有统计学意义(P<0.05);(3)多元回归分析显示,躯体健康总评〔OR=0.911,95%CI(0.896,0.958),P=0.032〕、心理健康总评〔OR=0.835,95%CI(0.711,0.926),P=0.008〕和PHQ-9评分〔OR=1.318,95%CI(1.115,1.481),P=0.022〕对低血糖反应发生的影响有统计学意义。结论生活质量和抑郁状态与低血糖反应有关。Objective To explore the impact of quality of life and depression on hypoglycemia in patients with type 2 diabetes mellitus （T2DM） . Methods A total of 458 patients were, according to whether they suffered from hypoglycemia within the past half year, divided into hypoglycemia group and non - hypoglycemia group. The single factor analysis was used ton investigate the differences between the two groups in scores of quality of life, depression, fasting blood sugar （FBG）, glycosylat- ed hemoglobin （HbA1c）, and body mass index （BMI） . Then the significant variables in single factor analysis were taken as the independent variables for multivariate regression analysis to explore the risk factors of hypoglycemia. Results （ 1 ） The BMI in the hypoglycemia group was significantly higher than that in the non - hypoglycemia group [ （24. 8±1.9） kg/m2 vs. （24. 2±1.8） kg/m2] （P 〈0. 05） . （2） The total scores of physical health [ （301.3±30. 3） vs. （312. 8±31.2） ] and psychological health [ （304.0±30. 8 ） vs. （316. 1±31.4） ~ were significantly lower in the hypoglycemia group than the non -hypoglycemia group （ P 〈0.01） . The score of Depression Score of Patient Health Questionnaire （ PHQ - 9） was significantly higher in the hypoglycemia group than in the non - hypoglycemia group （P 〈0. 05 ） . （ 3 ） The multivariate regression analysis revealed that the total scores of physical health [ OR = 0.911, 95% Cl （0. 896, 0. 958 ）, P = 0. 032 ] psychological health [ OR =0. 835, 95%CI （0.711, 0.926）, P=0. 008] and PHQ-9 [0R=1.318, 95%CI （1.115, 1.481）, P=0.022] were associated with hypoglycemia. Conclusion The quality of life and depression are associated with hypoglycemia in patients with T2DM.

关 键 词：糖尿病 2型 低血糖 生活质量 抑郁 

分 类 号：R587.1[医药卫生—内分泌]