慢性肝硬化患者肠球菌属感染及体外药敏分析  被引量:2

Enterococciinfections in patients with chronic cirrhosis and in vitro drug susceptibility testing

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作  者:钱贤忠[1] 俞世安[1] 毛根军[1] 张家敏[1] 郑樟栋[1] 马拥军[2] 

机构地区:[1]金华市中心医院肝胆胰外科,浙江金华321000 [2]金华市中心医院检验科,浙江金华321000

出  处:《中华医院感染学杂志》2013年第9期2215-2217,共3页Chinese Journal of Nosocomiology

摘  要:目的分析慢性肝硬化患者肠球菌属感染的现状及体外药敏特点,为临床合理用药提供参考。方法采集慢性肝硬化患者的各类标本进行细菌培养,并测定对常用抗菌药物的敏感性。结果所有研究的慢性肝硬化患者共检出肠球菌属138株,其中粪肠球菌102株,比例最高,占73.91%;屎肠球菌32株,占23.19%,居第2位;腹水中肠球菌属检出率最高,达到60.15%;检出高耐庆大霉素肠球菌属55株,占55.80%,耐氨苄西林肠球菌属30株,占21.74%,庆大霉素高水平耐药合并氨苄西林耐药肠球菌属28株,占20.29%;肠球菌属对万古霉素、利奈唑胺和替考拉宁的敏感率最高,均>90.00%;检出耐万古霉素肠球菌属2株,万古霉素中介肠球菌属3株。结论肠球菌属是慢性肝硬化患者感染的重要致病菌,尤以粪肠球菌为主;并发肠球菌属感染时,应高度重视细菌培养和药敏试验,为合理使用抗菌治疗提供依据;万古霉素、利奈唑胺和替考拉宁是治疗肠球菌属感染的首选药物。OBJECTIVE To analyze the current status of Enterococci infections in patients with chronic cirrhosis and observe the characteristics of the in vitro drug susceptibility so as to provide basis for the reasonable clinical medication.METHODS A variety of clinical specimens were sampled for the bacterial culture,and the drug susceptibility testing of common antibiotics was performed.RESULTS A total of 138 strains of Enterococci were isolated from all the study objects with chronic cirrhosis,among which there were 102(73.91%) strains of Enterococcus faecalis and 32(23.19%) strains of E.faecim.60.1% of all the Enterococci strains were found in the ascetic fluid.There were 55(55.80%) strains of gentamicin-resistant Enteroccci,30(21.74%) strains of ampicillin-resistant Enterococci,and 28(20.29%) strains of high level gentamicin combined with ampicillin-resistant Enterococci.The drug susceptibility rates to vancomycin,linezolid,and teicoplanin were more than 90.00%.There were 2 strains of vancomycin-resistant and 3 strains of vancomycin-intermediate Enterococci detected.CONCLUSION E.faecalis is the most prevalent species of pathogens causing infections in the patients with chronic cirrhosis.It is necessary to attach great importance to the bacterial culture and drug susceptibility testing so as to provide basis for the reasonable antibacterial treatment.Vancomycin,linezolid and teicoplanin are still the first choice for the treatment of Enterococci infections.

关 键 词:肠球菌属 耐药性 慢性肝硬化 

分 类 号:R378.1[医药卫生—病原生物学]

 

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