中医方剂现代研究的实践与思考——方剂功效物质组学的构想与建立  

Thinking and Practice of Modern Research on TCM Formulae——Proposal and Establishment of Formulae Efficacy Chemomics

作　　者：段金廒[1] 宿树兰[1] 刘培[1] 尚尔鑫[1] 范欣生[1] 钱大玮[1] 郭建明[1] 唐于平[1] 

机构地区：[1]南京中医药大学药学院/江苏省方剂高技术研究重点实验室江苏省方剂研究重点实验室/江苏省理血方剂创新药物工程中心,南京210023

出　　处：《世界科学技术-中医药现代化》2013年第2期159-166,共8页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：江苏省高校自然基金重大基础研究资助项目(06KJA36022):四物汤类方治疗妇科血瘀证原发性痛经的配伍规律与物质基础研究;负责人:段金廒;科学技术部国家"十一五"科技支撑计划(2006BAI06A02-01):三拗汤类方等中药药效评价研究;负责人:范欣生;江苏省高校自然科学重大基础研究项目(11KJA360002):用于妇科血瘀证原发性痛经的四物汤类方体内代谢特征研究;负责人:宿树兰;国家自然青年科学基金项目(81202880):香附四物汤干预气滞血瘀证原发性痛经的功效物质基础研究;负责人:刘培;国家自然青年科学基金项目(30902015):方剂图形化分析技术导向下的方剂效应成分群发现方法的构建;负责人:尚尔鑫;江苏省中药学优势学科(ysxk-2010);国家自然科学基金项目(30973885):乳香-没药对药配伍协同增效的分子机制研究;负责人:宿树兰

摘　　要：本文通过对四物汤、三拗汤等代表性类方较为系统的研究实践和学习体会,探索性地提出方剂功效物质组学的研究策略与方法学体系。方剂功效物质组学是研究功效物质组的组成及其相互关系以及与生物系统相互作用的方法学体系。作为新的概念和研究方法的探讨,作者提出了结构性的功效表征-效应信息群-功效物质组-作用机制的研究策略与相应方法技术体系。基于整体观和辨证论治原则有效关联中医临床功效、生物效应及效应物质的关系,从而建立了功效物质组及功效物质组学的方法学体系,为符合中医临床特点的方剂复杂效应物质基础研究提供了研究思路和方法技术支撑,有助于从功效物质层面深化认识经典方剂及其衍化类方的配伍关系与衍化规律的共性和差异,对中医临床应用具有指导意义,为方剂创新药物的发现提供引导。The research strategies, methodology and technology system of Formulae Efficacy Chemomics of TCM prescriptions were proposed based on our research and practice on Siwu decoction analogous formulae and San-ao decoction analogous formulae. The Formulae Efficacy Chemomics of TCM prescription is a methodology and tech- nology system to study the composition, interrelation, and interaction with biological systems of the effective chemome. The authors proposed the methodology and technology system of Function representation-Effect of infor- mation group- Efficacy Chemome-Action mechanisms. This strategy effectively associated with the clinical effica- cy, bioactivities and bioactive components, which lead to generate the Formulae Efficacy Chemomics. And the Formulae Efficacy Chemomics of TCM prescriptions provide a novel thoughts and methodology and technology a- greed with clinical characteristics of traditional Chinese Medicine for research on the bioactive components of TCMs. This helps to understand of the similarity and difference of combinational relations and derivation rules of formula and its analogous formulae, which is significant for the clinical application of traditional Chinese Medicine and guidance for discovering the original new drugs based on TCM formulae.

关 键 词：方剂 类方 功效物质组学 功效物质组 方-证-病关联 

分 类 号：R289[医药卫生—方剂学]