阿霉素凝胶体外释放度的测定  

Measure of in Vitro Release Rate of Adriamycin Gel

作　　者：柯玲玲[1] 游娟娟[1] 唐直婕[1] 赵德华[1] 尚京川[1] 

机构地区：[1]重庆医科大学药学院,重庆市渝中区医学院路1号400016

出　　处：《光谱实验室》2013年第3期1519-1522,共4页Chinese Journal of Spectroscopy Laboratory

摘　　要：建立阿霉素凝胶的制备方法,并考察其体外释放度。采用紫外分光光度法,恒温空气浴摇床装置(温度为37℃±0.5℃,转速为50r/min),以pH7.4的PBS为溶出介质测定阿霉素凝胶的释放度,检测波长为254nm。阿霉素凝胶在24h内释放较快,体外释放率达到56.67%左右,随后可持续稳定释药,释放时间可达到7天以上。阿霉素凝胶体外释放性能良好,具有明显的缓释作用。A method for preparation of adriamycin gel has been established, and its in vitro release rate was measured. The in vitro release rate of adriamycin gel was determined by ultraviolet spectrophotometry,the apparatuses of shaking zncubators（at 37℃-4-0. 5℃ ,speed for fifty revolutions per minute） ,pHT. 4 PBS as dissolution medium,with a detection wavelength at 254nm. Adriamycin gel could release quickly in the 24 hours, the in vitro release rates of the drug could reach to 56.67 %, and then sustainable stable released,release time could achieve more than 7 days. The performance of in vitro release of adriamycin gel is good, and adriamycin gel have a remarkable release effect.

关 键 词：阿霉素 凝胶 体外释放度 

分 类 号：TQ460.72[医药卫生—药物分析学] O657.32[化学工程—制药化工]