抗肿瘤中药新型药物传递系统的研究(三)——扶正固本类中药  

Progress in Novel Drug Delivery System of Anti-tumor Chinese Medicine (Part Three)——Fuzheng Guben Chinese Medicine

作　　者：陈锐娥[1] 王胜鹏[1] 胡杨洋[1] 陈美婉[1] 王一涛[1] 

机构地区：[1]中药质量研究国家重点实验室(澳门大学)/澳门大学中华医药研究院,澳门999078

出　　处：《世界科学技术-中医药现代化》2013年第2期201-206,共6页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：澳门大学研究基金项目(MYRG208(Y1-L4)-ICMS11-WYT):基于系统药理学的中药药剂学平台;负责人:王一涛

摘　　要：扶正固本类中药可通过益气健脾、养阴补血、温阳补肾等方法,增强机体抗肿瘤的免疫功能,广泛应用于肿瘤的辅助治疗。现代中药药理研究表明,扶正固本类中药如麦门冬、玉竹、天门冬以及山茱萸等,主要是通过调控宿主抗肿瘤免疫应答相关的免疫抑制因子,从而发挥肿瘤的免疫治疗效果。然而,该类中药中的有效成分(多糖、皂苷等)多存在吸收困难、生物利用度低等缺陷,影响了其治疗效果。近年来,使用新型传递系统解决药物存在的溶解度、稳定性和不良反应等问题已成为该类中药研究开发的一大热点。本文主要对近几年来备受关注的几种新型抗肿瘤中药剂型,以及在肿瘤治疗方面比较常见的5种扶正固本类抗肿瘤中药包括人参、当归、黄芪、灵芝和党参等新型药物传递系统进行综述,旨在为该类抗肿瘤中药新剂型的研究与开发提供参考和依据。Fuzheng Guben （FZGB） Chinese medicine, or tonification Chinese medicine, is widely used to treat various malignant tumors through activating the spleen and replenishing qi, nourishing yin and enriching the blood, warming yang and reinforcing kidney. Modern Chinese medicine pharmacological researches have demon- strated that this kind of anti-tumor herbs is able to control immunosuppressive factors related to anti-tumor im- mune and response in host, which plays an important role in anti-cancer treatment. However, most of the active ingredients from FZGB Chinese medicine have shortcomings such as difficult absorption and low bioavailability. Hence, the treatment effect is not satisfied. During the past few decades, novel drug delivery system has become a hot research topic for the development of FZGB Chinese medicine. This paper mainly focused on the new drug delivery system of FZGB Chinese medicine, especially five commonly used medicine, namely Ginseng, Angelica rma, and Codonopsis pilosula. This study is aimed to offer more references and evidences for the development of new formulations in anti-tumor Chinese medicine.

关 键 词：抗肿瘤中药 新型药物传递系统 扶正固本类中药 

分 类 号：R283[医药卫生—中药学]