基于改善微循环药效的天麻素与葛根素配伍合理性研究  

Study on Compatibility Rationality of Gastrodin and Puerarin based on Improving Microcirculation

作　　者：姜丽[1] 王玉蓉[1] 曹唯仪[1] 黄镇林[1] 杜清华[1] 

机构地区：[1]北京中医药大学中药学院,北京100102

出　　处：《世界科学技术-中医药现代化》2013年第2期244-248,共5页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：北京中医药大学复方中药制药研究创新团队(2011-CXTD-13);负责人:杜守颖

摘　　要：目的:研究天麻素与葛根素配伍后在抗凝血及抗血小板聚集方面的作用,探讨其配伍应用的合理性。方法:以体内外活化部分凝血活酶时间(APTT)和二磷酸腺苷(ADP)诱导的血小板聚集率为指标,分别评价药物及其配伍后的抗凝血和抗血小板聚集作用。结果:天麻素和葛根素在一定剂量范围内均具有抗凝血、抗血小板聚集作用,且二药作用强于单一用药。结论:一定剂量天麻素和葛根素配伍后,其抗凝血及抗血小板聚集作用均有所增加。This article was aimed to study the effect of anticoagulation and anti-platelet aggregation after the administration of both gastrodin and puerarin in order to explore the rationality of this combination. The APTY and ADP-induced anti-platelet aggregation rate in vitro/vivo were selected as indexes to anti-platelet aggregation effects of the drugs. The results showed that both gastrodin evaluate anticoagulation and and puerarin have effects of anticoagulation and anti-platelet aggregation. And these effects can be promoted when gastrodin and puerarin are co-used. It was concluded that the anticoagulation and anti-platelet aggregation effects of gastrodin and puerarin can be enhanced when used in combination in a certain range of dosage.

关 键 词：天麻素 葛根素 配伍合理性 APTT 抗血小板聚集 

分 类 号：R286.42[医药卫生—中药学]