莫西沙星与左氧氟沙星治疗中青年耐多药肺结核病的疗效比较  

Efficacy Comparison on Moxifloxacin vs.Levofloxacin in the Treatment of Multi-drug Resistant Pulmonary Tuberculosis with Young and Middle-aged Patients

作　　者：姚君[1] 钟皓成[2] 章丹丹[1] 

机构地区：[1]杭州市红十字会医院药剂科,杭州310016 [2]杭州市预防保健门诊部职业病科,杭州310014

出　　处：《中国药房》2013年第20期1884-1886,共3页China Pharmacy

摘　　要：目的:比较莫西沙星与左氧氟沙星治疗中、青年耐多药肺结核病(MDR-PTB)的临床疗效及安全性。方法:将杭州市红十字会医院2007年6月-2011年2月收治的76例MDR-PTB中、青年患者根据治疗方式不同分为治疗组(40例)与对照组(36例)。治疗组患者口服莫西沙星片0.4g/d,对照组患者口服左氧氟沙星片0.5g/d,两组同时辅以其他相同的抗结核药物治疗,疗程均为12个月。治疗后观察两组患者疗效、痰菌转阴率、不良反应发生情况。结果:治疗组患者总有效率(92.5%)、痰菌转阴率(87.5%)显著高于对照组(75.0%、66.7%),差异有统计学意义(P<0.05);两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论:与左氧氟沙星比较,莫西沙星联合常规抗结核方案治疗MDR-PTB疗效、痰菌转阴率较好,不良反应发生率较低。OBJECTIVE：To compare the clinical efficacy and saftey of moxifloxacin vs.levofloxacin in the treatment of multi-drug resistant pulmonary tuberculosis（MDR-PTB） with young and middle-aged patients.METHODS：The 76 young and middle-aged patients from Jun.2007 to Feb.2011 who received therapy on MDR-PTB in red cross hospital of Hangzhou as research subjects were divided into treatment group（40 cases） and control group（36 cases）.Treatment group was given moxifloxacin（0.4 g/d,po）and control group was received levofloxacin（0.5 g/d,po）.Both groups were treated with the same chemotherapy for 12 month.RESULTS：The effective rate（92.5%） and time of sputum negative conversion（87.5%） of treatment group was significantly higher than control group（75.0%,66.7%,P0.05）.Adverse drug reaction rate between 2 groups were close,the difference was not significant（P0.05）.CONCLUSIONS：Compared with levofloxacin,moxifloxacin combined with traditional method in the treatment of MDR-PTB has better clinical efficacy and sputum negative conversion,but lower adverse drug reaction.

关 键 词：莫西沙星 左氧氟沙星 耐多药肺结核病 疗效比较 

分 类 号：R521[医药卫生—内科学]