部分液体通气对内毒素肺损伤肺表面活性物质系统超微结构的影响  

The effect of partial liquid ventilation on the ultrastructure of pulmonary surfactant system in endotoxin-induced acute lung injury in rats

作　　者：邓小明[1] 李金宝[1] 朱科明[1] 

机构地区：[1]第二军医大学长海医院麻醉科,上海200433

出　　处：《中国病理生理杂志》2000年第8期734-737,共4页Chinese Journal of Pathophysiology

摘　　要：目的 :研究部分液体通气对内毒素肺损伤大鼠肺表面活性物质 (pulmonarysurfactant,PS)系统超微结构的影响。方法 :运用电子显微镜细胞化学方法 ,对内毒素肺损伤鼠PS系统进行观察及部分液体通气对其的影响。结果 :内毒素肺损伤后可见PS层失去连续性 ,呈断裂或堆积 ;肺泡II型细胞内板层小体、线粒体空泡化 ,少数发生坏死并崩解、脱落进入肺泡腔。液体通气 +肺损伤组PS系统损伤程度明显低于内毒素肺损伤组。结论 :液体通气可明显改善内毒素肺损伤时PS系统的损伤。AIM: To study the effect of partial liquid ventilation on the ultrastructure of pulmonary surfactant(PS) system in endotoxin-induced acute lung injury METHODS: The effect of partial liquid ventilation on the ultrastructure of PS system in endotoxin-induced acute lung injury was observed with electronmicroscope histochemistry. RESULTS: There was ultrastructure impairment of PS system in endotoxin-induced acute lung injury, the pulmonary surfactant layer was discontinuous, lamellar bodies and plasmosomes in type Ⅱ pneumonocytes vacuolated, and a few of them were even necrotized and disrupted into the alveolar space. The pulmonary surfactant layer was still continuous, the vacuolation of lamellar bodies and plasmosomes in type Ⅱ pneumonocytes was little with partial liquid ventilation. CONCLUSION: Partial liquid ventilation can lessen the impairment of PS system in endotoxin-induced acute lung injury in rats.

关 键 词：肺表面活性剂 肺损伤 超微结构 内毒素 

分 类 号：R655.302[医药卫生—外科学]