泻热化痰法对急性脑梗死痰热证的血液流变学和血清sICAM-1水平的影响  

Hemorheology Indexes and Serum sICAM-1 Levels Influence of Xiere Huatanfa in Treating Acute Ischemic Apoplexy

作　　者：高秀兰[1] 张春玲 

机构地区：[1]山东中医药高等专科学校,山东莱阳265200 [2]青岛市中心医院,山东青岛266042

出　　处：《中国实验方剂学杂志》2013年第10期307-310,共4页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:探讨泻热化痰法对急性脑梗死痰热证的血液流变学指标和血清细胞间黏附分子(sICAM-1)水平的影响。方法:将60例急性脑梗死痰热证患者随机分为治疗组和对照组(每组30例),疗程分为2个阶段共21 d。观测指标为血流变学、sICAM-1及安全性指标等,并结合神经功能缺损评分标准进行评定。结果:泻热化痰法不仅能改善患者的神经功能,而且能明显改善病人的临床症状(P<0.05),说明治疗组优于对照组;治疗后两组血流变均得到不同程度改善,而治疗组优于对照组;治疗组血清sICAM-1浓度低于对照组,差异有显著性。结论:泻热化痰法对痰热证急性脑梗死患者具有良好的治疗效果,进一步丰富了泻热化痰方治疗急性脑梗死痰热证的作用机制。Objective： To study hemorheology indexes and serum soluble intercellular adhesion molecule-1（sICAM-1） levels influence of ＇Xiere Huatanfa＇. Method： During clinical research,60 cases were randomly divided into testing group and contrasting group（30 cases each group）.There were 2 phases in one period of treatment amounting to 21days.Some indexes including hemorheology indexes, Serum sICAM-1 levels and safe indexes were examined, at the same time,we examined the mind,language and movement function. Result： Xiere Huatanfa can not only improve patient＇s functions,but also obviously improve the clinic symptoms（P〈0.05）, it shows testing group was better than contrasting group.Experiment indicates, After treatment, two groups of hemorheology indexes were improved in different degrees, and testing group was better than contrasting group. The concentration of serum sICAM-1 in testing group was lower than in the contrasting group, there was significant difference. Conclusion： Xiere Huatanfa is obviously effective on the treatment of cerebral ischemic stroke with phlegm-heat syndrome and enrich the mechanism of Xiere Huatanfang.

关 键 词：急性脑梗死 痰热证 泻热化痰法 血流变学 细胞间黏附分子 

分 类 号：R285.5[医药卫生—中药学]