康艾注射液联合放化疗治疗中晚期食管癌  

Evaluation on Kang’ai Injection Combined with Chemoradiation Scheme for Treating Middle-late Esophageal Cancer

作　　者：程宏忠[1] 王平[1] 毛新[1] 彭浩[1] 熊健[1] 汪国平[1] 

机构地区：[1]云南省第一人民医院,昆明650032

出　　处：《中国实验方剂学杂志》2013年第10期337-339,共3页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:探讨康艾注射液联合放化疗方案治疗对中晚期食管癌的临床效果。方法:67例中晚期食管癌患随机分为观察组34例和对照组33例。两组均采用放射治疗+化疗,观察组加用康艾注射液,40 mL,用5%葡葡糖或0.9%生理盐水250 mL稀释后静脉滴注,2次/d。疗程6周。观察两组疲乏状况,评价生活质量及毒副反应。结果:治疗后观察组疲乏程度明显轻于对照组(P<0.05);治疗后观察组生活质量评分为(57.54±4.77)分,优于对照组的(51.45±6.12)分(P<0.05);观察组出现Ⅲ度骨髓抑制7例(20.58%),低于对照组的15例(45.45%)(P<0.05);观察组Ⅲ度骨髓抑制出现时间(21.5±5.7)d,晚于对照组的(15.7±6.9)d(P<0.01);观察组有效率55.88%,对照组39.39%,两组差异不明显。结论:康艾注射液联合放化疗治疗中晚期食管癌患者能减轻患者的疲乏程度,减轻骨髓抑制,推迟Ⅲ度骨髓抑制发生的时间,提高了患者的生活质量。Objective： To study the effect of Kang＇ai injection combined with chemoradiation scheme on treating middle-late esophageal cancer. Method： Sixty-seven cases with middle-late esophageal cancer were randomly divided into observation group and control group, 34 cases respectively. Two groups were all given radiation therapy and chemotherapy, the observation group supplemented by Kang＇ai injection, 60 mL, with 5% glucose 250 mL dilution by intravenous drip daily for 6 weeks as the treatment. The fatigue status was observed, and the quality of life and side reactions were evaluated for the two groups. Result： After treatment, the fatigue in observation group was significantly lighter than that in the control group （P〈0.05）; the score of life quality（57.54±4.77） in the observation group was better than that （51.45±6.12） in the control group （P〈0.05）. The Ⅲ degree suppression of bone marrow was 7 cases in observation group （20.58%）, lower than 15 cases in the control group of （45.45%） （P〈0.05）. The average appearance time in observation group was （21.5±5.7） d, later than （15.7±6.9） d of control group （P〈0.01）. The effective rate was 55.88% in observation group, and 39.39% in control group, the difference was not obvious. Conclusion： Kang＇ai injection combined with chemotherapy and radiation for patients with middle-late esophageal cancer can reduce fatigue degree, reduce bone marrow suppression, delayed the appearance of Ⅲ degree bone marrow suppression and improve the patient＇s quality of life.

关 键 词：食管癌 康艾注射液 辅助治疗 

分 类 号：R287[医药卫生—中药学]