美罗培南持续输注治疗呼吸机相关性肺炎的临床效果  

The clinical efficacy of meropenem by continuous infusion in ventilator-associated pneumonia

作　　者：郭端[1] 贾超[1] 许治华[1] 

机构地区：[1]绵阳市中心医院重症医学科,四川绵阳621000

出　　处：《四川医学》2013年第3期331-332,共2页Sichuan Medical Journal

摘　　要：目的研究美罗培南静脉持续输注治疗呼吸机相关性肺炎的临床效果。方法将43例呼吸机相关性肺炎的患者随机分为两组,持续输注组22例,美罗培南3g/24h静脉持续输注;间断输注组21例,美罗培南1g输注0.5h,1次/8h。结果美罗培南静脉持续输注组与间断输注组比较,治疗成功率明显提高,患者机械通气时间缩短,患者经济支出明显降低,两组不良反应的发生差异无统计学意义。结论美罗培南持续输注治疗呼吸机相关性肺炎,疗效较间断输注方案更佳,可减少医疗费用,且安全性好。Objective To evaluate the clinical efficacy of Meropenem by continuous infusion in ventilator-associated pneumonia. Methods 43 patients with ventilator-associated pneumonia were randomly divided into two groups. One group reeeived meropenem by continuous infusion （3g over 24h）, the other by intermittent infusion （ lg over 30rain, every 6h）. Results The group receiving medication by continuous infusion showed a greater clinical cure rate, shorter mechanical ventilation time and less economic cost than the group treated with intermittent infusion. There were no significant differences of adverse events between the two groups. Conclusion Meropenem administered by continuous infusion have more clinical efficacy, less economic cost than intermittent infusion ,and the administration by continuous infusion is safe.

关 键 词：呼吸机相关性肺炎 美罗培南 静脉持续输注 

分 类 号：R563.1[医药卫生—呼吸系统]