脑外伤性癫痫患者炎性细胞因子和C反应蛋白变化及其临床意义  

Study on clinical significance of changes in blood levels of inflammatory cytokines and C reactive protein in patients with post cerebrotraumatic epilepsy

作　　者：彭威[1] 张树方[1] 何晓云[1] 金维[1] 

机构地区：[1]上海市第八人民医院神经外科,上海200235

出　　处：《临床和实验医学杂志》2013年第10期770-771,773,共3页Journal of Clinical and Experimental Medicine

摘　　要：目的探讨脑外伤性癫痫患者炎性细胞因子白细胞介素-2(IL-2)、白细胞介素-6(IL-6)、肿瘤坏死因子α(TNF-α)和C反应蛋白(CRP)的变化及意义。方法选自2009年1月至2012年1月收治的脑外伤并发癫痫的患者37例,采用采用酶联免疫吸附法检测检测患者外周血中第1、3、5、7 d时IL-2、IL-6、TNF-α和CRP的水平,同时选同期20例健康人群作为对照组。结果两组1、3、5、7 d IL-2、IL-6、TNF-α和CRP水平比较差异有显著性(P<0.05,P<0.01)。脑外伤性癫痫中度、重度组IL-2、IL-6、TNF-α和CRP水平均显著高于轻度组(P<0.05)。结论脑外伤性癫痫患者外周血中IL-2、IL-6、TNF-α和CRP水平显著升高且IL-2、IL-6、TNF-α和CRP水平与病情严重程度有关,提示炎性因子与CRP对癫痫的发作有影响。Objective To explore the clinical significance of changes in blood levels of inflammatory cytokines and C reactive protein in patients with post cerebrotraumatic epilepsy. Methods Thirty seven cases of post cerebrotraumatic epilepsy during January 2009 to January 2012 were allocated in this study, their blood levels of IL- 2, IL- 6, TNF -α and CRP were examined by enzyme -linked immunosorbent assay at 1 st , 3rd , 5th and 7th d, and 20 healthy persons were selected as control group. Results The blood levels of IL - 2, IL - 6, TNF -α and CRP were compared between these 2 groups. The blood levels of IL - 2, IL - 6, TNF - αand CRP in moderate and severe groups were significantly higher than those of mild group （ P 〈 0. 05 ）. Conclusion The blood levels of IL - 2, IL - 6, TNF - α and CRP are significantly increased in patients with post cerebrotranmatic epilepsy, and blood levels of IL -2, IL -6, TNF -α and CRP are correlated to the severity of disease, thus it indicates that the inflammatory factors and CRP may influence the onset of epilepsy.

关 键 词：脑外伤性癫痫 IL-2 IL-6 TNF-α CRP 

分 类 号：R651.1[医药卫生—外科学] R446.6[医药卫生—临床医学]