血府逐瘀胶囊对心脏X综合征患者血管内皮功能的影响  

Influence of Xuefu Zhuyu Capsule on Endothelial Function in Patients with Cardiac Syndrome X

作　　者：陈玉静[1] 黄小波[1] 陈文强[1] 王宁群[1] 褚研研[1] 

机构地区：[1]首都医科大学宣武医院

出　　处：《中西医结合心脑血管病杂志》2013年第5期524-525,共2页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：国家自然科学基金项目(No.81102624);北京市中医管理局青年科研资助项目(No.QN2011-07);首都中医药及护理学研究专项(No.12ZYH04)

摘　　要：目的观察血府逐瘀胶囊对心脏X综合征患者血管内皮功能的影响。方法将60例心脏X综合征患者随机分为血府逐瘀胶囊组和对照组,每组30例。对照组予常规西药治疗,血府逐瘀胶囊组在常规西药治疗基础上加服血府逐瘀胶囊,疗程2周。观察患者入院第3天及治疗后肱动脉血流介导的血管扩张率(flow mediated dilation,FMD)、血浆一氧化氮(NO)水平变化。结果治疗后血府逐瘀胶囊组肱动脉血流介导的血管扩张率为(18.36±2.23)%,较同组治疗前(8.42±1.15)%及对照组治疗后(15.51±4.14)%均显著升高(P<0.05);治疗后血府逐瘀胶囊组NO水平为(85.30±13.51)μmol/L,较同组治疗前(57.32±17.94)μmol/L及对照组治疗后(75.40±16.73)μmol/L均显著升高(P<0.05)。结论心脏X综合征患者服用血府逐瘀胶囊后能显著改善血管内皮功能,对内皮细胞具有保护作用。Objective To investigate the influence of Xuefu Zhuyu capsule（XZC） on endothelial function in patients （pts） with car diac syndrome X （CSX）. Methods Sixty pts with CSX were randomly assigned to two groups：Control group （n=30） treated with routine treatment,and treatment group （n= 30） treated with XZC on the basis of routine treatment for two weeks. Plasma nitric oxide （NO） levels and flow - mediated dilation （FMD） rates were detected at third day of hospitalization and again after two weeks. Results Compared with pretreatment, FMD was improved in both groups after treatment. FMD was （18. 36 ± 2. 23）% in treatment group and （15.51±2.14）% in control group（P〈0.05）. After treatment, the level of plasma NO was increased in treatment group（P〈0.05）. The level of plasma NO in treatment group was 85.30 μmol/L/13.51 μmol/L,which was higher than that in con trol group（75.4 μmol/L± 16. 73 μmol/L,P〈0.05）. Conclusion XZC could significantly improve endothelial function in pts with CSX,and had protective effect on endothelial cells.

关 键 词：心脏X综合征 血府逐瘀胶囊 血管扩张率 血管内皮功能 一氧化氮 

分 类 号：R259[医药卫生—中西医结合]