探讨不同方式血液净化对维持性血液透析患者抵抗素的清除作用  

The discussion of the clearance of different blood purification methods on resistin in patients with maintenance hemodialysis

作　　者：朱慧敏[1,2] 夏天[1] 师军华 王东红[2] 

机构地区：[1]天津医科大学,天津300450 [2]天津市第五中心医院肾内科

出　　处：《现代预防医学》2013年第10期1985-1987,F0003,共4页Modern Preventive Medicine

摘　　要：目的探讨不同方式血液净化对维持性血液透析(MHD)患者血抵抗素的清除及意义。方法 MHD患者61例按随机数字表法分为联机血液透析滤过(OL-HDF)组31例和血液透析联用血液灌流(HD+HP)组30例。ELISA方法检测治疗前后血抵抗素,同时测定血尿素氮、肌酐、尿酸、血磷浓度等。结果 OL-HDF和HD+HP组患者治疗后血尿素氮、肌酐、尿酸、血磷及血抵抗素均较治疗前显著下降(P﹤0.01)。血尿素氮、肌酐、尿酸、血磷(P﹤0.01),血抵抗素(P﹤0.05),治疗前后差值OL-HDF组大于HD+HP组。结论 OL-HDF和HD+HP治疗后抵抗素均显著下降(P﹤0.01)。OL-HDF和HD+HP均能清除抵抗素,OL-HDF组较HD+HP组清除抵抗素更显著。OBJECTIVE To investigate the removal of resistin and significance in different type hemopurification techniques for maintenance hemodialysis patients （MHD）. METHODS A total of 61 MHD patients were randomly divided into on-line hemodiafiltration group （OL-HDF, n = 31） and hemodialysis with hemoperfusion group （HD＋HP, n = 30）. ELISA was used for determination of serum resistin, meanwhile urea, creatinine, uric acid and phosphate were measured before and after dial- ysis. RESULTS Serum urea, creatinine, uric acid, phosphate and resistin decreased markedly after treatment with OL-HDF or HD＋HP （P 〈 0.01）. Urea, creatinine, uric acid, phosphate of OL-HDF group, decreased more obviously than that in HD＋ HP group （P 〈 0.01）. Reducition of resistin in OL-HDF group was also more evident than that in HD＋HP group （P 〈 0.05）. CONCLUSION Serum urea, creatinine, uric acid, phosphate and resistin decrease significantly after treatment with OL-HDF and HD＋HP （P 〈 0.01）. OL-HDF and HD＋ HP can efficiently eliminate resistin. OL-HDF eliminates resistin more markedly than HD＋HP.

关 键 词：血液透析滤过 血液灌流 抵抗素 

分 类 号：R459.5[医药卫生—治疗学]