P-选择素、TM和vWF对早期识别重症急性胰腺炎的价值  

Value of serum P-selection, TM and vWF in early identification of severe acute pancreatitis

作　　者：许建民[1] 田湘萍[1] 刘秀珍[1] 董涛[1] 张银华[1] 赵存新[1] 杨焕东[2] 

机构地区：[1]潍坊市益都中心医院消化内科,山东青州262500 [2]潍坊市益都中心医院普外科,山东青州262500

出　　处：《中国现代普通外科进展》2013年第4期298-300,共3页Chinese Journal of Current Advances in General Surgery

摘　　要：目的:探讨血管内皮损伤标志物P-选择素、血栓调节蛋白(TM)、血管性假血友病因子(vWF)对早期识别重症急性胰腺炎(SAP)的价值。方法:采用酶联免疫吸附测定法,分别测定轻症急性胰腺炎患者(53例)、SAP患者(21例)、正常对照组(16例)的血管内皮细胞损伤标志物P-选择素、TM、vWF水平。结果:SAP患者P-选择素(99.8±21.7μg/L)、TM(66.70±12.27 ng/mL)、vWF(186%±38%)含量升高,与轻症(73.6±16.1μg/L、9.80±6.98 ng/mL、141%±30%)和正常对照组(14.5±4.5μg/L、4.28±0.92 ng/mL、106%±21%)比较差异有统计学意义(P<0.05)。结论:急性胰腺炎患者均存在不同程度的血管内皮细胞损伤及凝血和纤溶系统的激活,检测血管内皮损伤标志物P-选择素、TM、vWF含量可作为SAP早期识别、病情进展、预后判定的指标之一。Objective： To study the value of serum P-selection, TM and vWF in early identifi- cation of severe acute pancreatitis. Methods： P-selection, TM and vWF were determined by EL ISA. Plasma P-selection,TM,vWF were measured in 21 patients with severe acute pancreatitis, 53patients with mild acute pancreatitis and 16 healthy subjects as controls. Results： Compared with the control group （14.5 ±4.5 μg/L,4.28 ±0.92 ng/mL,106% ±21%） and the MAP group （73.6 ± 16.1 μg/L,9.80 ±6.98 ng/mL,141% ±30%）, the plasma P-selection （99.8 ±21.7 μg/L）,TM（66.7± 12.27 ng/mL）.vWF （.186% ± 38%）were elevated in severe acute pancreatitis （P〈0.05）. Conclusion： Activation of coagulation and fibrinotysis and injury of vascular endothelium exist in acute pancreatitis. The changes of markers to endothelium cell injury P-selection, thrombomodulin （TM） and von willebrand factor （vWF） levels can be used as one of the indicators for assessment of the development, and the pronosis of the acute pancreatitis.

关 键 词：重症急性胰腺炎 P-选择素 血栓调节蛋白 血管性假血友病因子 

分 类 号：R657.51[医药卫生—外科学]