骨细胞在骨重建中的功能与作用  

Osteocytes and bone remodeling

作　　者：王斯晟[1] 桂斌捷[1] 周健[1] 

机构地区：[1]安徽医科大学第一附属医院骨科一病区,安徽省合肥市230022

出　　处：《中国组织工程研究》2013年第11期2060-2066,共7页Chinese Journal of Tissue Engineering Research

摘　　要：背景:骨细胞在骨组织中形成遍布矿化骨基质的三维细胞网络,可以作为骨代谢重要的调节因子。目的:分析讨论骨细胞在骨重建过程中功能的研究进展。方法:应用计算机检索PubMed数据库、ELSEVIER数据库1990年1月至2012年4月有关骨细胞功能及骨重建的文章,检索词"osteocytes,remodeling"。同时检索万方数据库1990年1月至2012年4月相关文章,检索词"骨细胞,骨重建"。选出有代表意义的41篇进行归纳总结,排除重复或类似的同一研究。结果与结论:骨细胞对于应力的感受与反应使得骨细胞在骨重建中发挥着重要的作用,包括骨重建的启动、骨吸收抑制以及骨形成的调节。研究表明骨细胞的突触可能作为应力造成细胞变形的直接感受器。实验证明骨细胞受应力刺激后可能激活Wnt/Lrp通路作为硬化蛋白的负调节因子,而硬化蛋白本身是骨形成的负调节因子,骨细胞在重建过程中可能还承担着控制骨基质填充速度的角色。BACKGROUND： Osteocytes that form a three-dimensional cellular network inside the mineralized bone matrix are a critical regulator of bone metabolism, OBJECTIVE： To explore the progress in studies of osteocytes effect on bong remodeling METHODS： The articles on the role of osteocytes and bone remodeling were searched by computer in the PubMed and ELSEVIER databases from January 1990 to April 2012 using the key words of ＂osteocytes,remodeling＂. Meanwhile, Wanfang database was retrieved to identify the related articles published between January 1990 and April 2012 with the keywords of ＂osteocytes, remodeling＂ in Chinese. After the full texts on the subject were founded, 41 articles were chosen and summarized. Repetition and analogous researches were excluded. RESULTS AND CONCLUSION： Osteocytes that sense and response to mechanical stress play a critical role in bone remodeling, including initiating bone remodeling, inhibiting bone resorption and controlling bone formation. Studies have demonstrated that osteocyte synapses can serve as the direct receptor for stress-induced cell deformation. After stress stimulation, osteocytes can activate the Wnt/Lrp pathway serving as a negative regulator of hardened protein that is a negative regulator of bone formation, and osteocytes also play a role in the control of bone matrix filling during bone remodeling.

关 键 词：组织构建 组织构建学术探讨 骨细胞 破骨细胞 重建 应力感受 应力刺激 突触 骨吸收抑制 硬化蛋白 牙本质基质蛋白1 综述文献 

分 类 号：R318[医药卫生—生物医学工程]