“清热解郁方”合并氟西汀治疗难治性抑郁症的疗效观察  

Therapeutic effect of the decoction of clearing heat and relieving depression combine with fluoxetine in the treatment of treatment resistant depression

作　　者：袁海宁[1] 贾竑晓[1] 朱虹[1] 田金洲[2] 时晶[2] 

机构地区：[1]首都医科大学附属北京安定医院精神科,北京100088 [2]北京中医药大学东直门医院脑病科,北京100700

出　　处：《首都医科大学学报》2013年第2期211-213,共3页Journal of Capital Medical University

基　　金：北京市中医药科技发展基金资助项目(JJ2005-16);北京市科委研发攻关项目(D10110704780000)~~

摘　　要：目的探讨清热养阴解郁方法治疗难治性抑郁症的疗效。方法共55例符合难治性抑郁症诊断标准的患者采用数字表法随机分入氟西汀合并中药治疗组或氟西汀治疗组,疗程12周,进行汉密尔顿抑郁量表(Hamilton Depression Scale,HAMD)、汉密尔顿焦虑量表(Hamilton Anxiety Scale,HAMA)评定。结果与单用氟西汀治疗的患者相比,合并中药治疗能较好地缓解难治性抑郁症患者的焦虑、抑郁症状,治疗第8周,12周末时,2组患者的疗效差异有统计学意义(P<0.05或P<0.01);治疗第4周末时合并服用中药的患者抑郁焦虑情绪即有所缓解(P<0.01)。结论 "清热解郁方"对氟西汀治疗难治性抑郁症患者有增效作用。Objective To observe the effect of the decoction of clearing heat and relieving depression combined with fluoxetine in the treatment of treatment-resistant depression. Methods Fifty-five cases of treatment-resistant depression were randomized into the control group or study group. The control group was treated with fluoxetine, while the study group was treated with fluoxetine combined with Chinese medicine. The scores of Hamilton Depression Scale（HAMD） and Hamilton Anxiety Scale（HAMA） were observed and compared. Results After treatment, the scores of HAMD in study group decreased significantly compared with baseline group at week 8 and week 12 （P〈0.05 and P〈0.01 ）. The scores of both HAMA in study group decreased significantly compared the control group at week 8 and week 12（P〈0.05 or P〈0.01 ）. This decrease begins with the fourth week till the end of the study. Conclusion The therapy with the decoction of clearing heat and relieving depression could improve the effect of fluoxetine on treatment-resistant depression.

关 键 词：清热解郁 中药 氟西汀 难治性抑郁症 

分 类 号：R971.43[医药卫生—药品]