Role of microRNAs in endothelial function  

作　　者：CHEN Xian-bing ZHENG Si-dao WU Hong-jin 

机构地区：[1]Clinical Trials Centre , Department of Cardiology , Beijing Hospital of Integrated Traditional Chinese and Western Medicine, Beijing 100039, China

出　　处：《Chinese Medical Journal》2013年第9期1779-1786,共8页中华医学杂志（英文版）

基　　金：The project was supported by grants from the National Natural Science Foundation, China （No.81173367 and No. 81273890）.

摘　　要：MicroRNAs （miRNAs） are a class of short, single-stranded, noncoding RNAs that modulate avariety of biological functions as negative regulators gene expression. Post-transcriptional regulation of by miRNAs is crucial in many aspects including cell proliferation and death. They play important regulatory roles in endothelial cell function, which are significant for the treatment of endothelial dysfunction and related metabolic disorders. This review summarizes current insights into the functions of miRNAs, focusing specifically on the regulation of endothelial function.MicroRNAs （miRNAs） are a class of short, single-stranded, noncoding RNAs that modulate avariety of biological functions as negative regulators gene expression. Post-transcriptional regulation of by miRNAs is crucial in many aspects including cell proliferation and death. They play important regulatory roles in endothelial cell function, which are significant for the treatment of endothelial dysfunction and related metabolic disorders. This review summarizes current insights into the functions of miRNAs, focusing specifically on the regulation of endothelial function.

关 键 词：MICRORNA endothelial cell gene regulation 

分 类 号：Q591.2[生物学—生物化学] Q522